‘你多大年龄’用英语怎么说

nephew[英][u02c8nefju:] [美][u02c8nu025bfju] 生词本简明释义n.侄子，外甥复数：nephews以下结果由 金山词霸 提供柯林斯高阶英汉词典网络释义同反义词1.N-COUNT外甥；侄子Someone"s nephew is the son of their sister or brother. I am planning a 25th birthday party for my nephew.我在为侄子筹划他25岁的生日聚会。以下结果由 金山词霸 提供例句Two weeks later they arrested narciso"s nephew.两周之后警察逮捕了narciso的侄子。

nephew英 [u02c8nefju:] 美 [u02c8nu025bfju] n. 侄子，外甥 侄子； 外甥； 侄子，外甥； 男性晚辈 复数：nephews 可数名词外甥;侄子 Someone"s nephew is the son of their sister or brother. I am planning a 25th birthday party for my nephew. 我在为侄子筹划他25岁的生日聚会。1 He entrusted the task to his nephew. 他把这任务托付给了他的侄儿。 2. The Richards I and II implants (Smith &Nephew) have a deep, trochlear groove. RichardsI和II植入物(Smith&Nephew)有一条很深的限制性的滑车凹槽。 来自互联网3. In February 1967, she began a dalliance with Robin Douglas-Home, 35, a talented and troubled pianist and the nephew of a former prime minister. 1967年2月，玛格丽特与一位前首相的侄子、才华横溢但天性伤感的钢琴家35岁的罗宾·道格拉斯-霍姆开始了一段情缘。 4. I am planning a 25th birthday party for my nephew. 我在为侄子筹划他25岁的生日聚会。 5. It was the nephew of Monseigneur. 是侯爵的侄子。

词典结果：nephew[英][u02c8nefju:][美][u02c8nu025bfju]n.侄子，外甥; 复数：nephews具体读音 http://fanyi.baidu.com/#en/zh/nephew

魅族手机上的人啊！亿丰田野生活啊盾有钱啊啊啊。

应该是：nephew 英[ˈnefjuː] 美[ˈnefjuː] n. 侄子; 外甥; [例句]Last month a shopkeeper"s nephew was shot dead上个月一名店主的侄子被枪杀了。[其他] 复数：nephews

nephew 侄子niece 侄女

停车场“p”上的"he"他,是新来"ne___w"的侄子ne_p_he_w

nephewsn.侄子，外甥( nephew的名词复数 )nephew英 [u02c8nefju:] 美 [u02c8nu025bfju] n.侄子，外甥

nephew[ˈnefju:]释义：n. 侄子，外甥变形：复数. nephews

首先，nephew确实是既可以指侄子也可以指外甥，所以two nephews在现实生活中有可能说的是一个侄子一个外甥。在精确翻译的时候会根据上下文语境，找出到底是侄子还是外甥。但是在我们日常翻译的时候我会建议您大致地翻译就可以了，所以two nephews就只翻译成“两个侄子”就行了，因为没有语境，所以不用精确翻译。第二，橘子和橙子的翻译是不一样的。orange是橙子，橘子是mandarin。第三，煎、炸、炒的翻译也是不一样的。煎是fry，炸是deep fry，炒是stir fry。希望可以帮到您。

nephew对应： a son of your brother or sisternephew反义：niece private对应： privy adj personal adj intimate adj.private反义：official formal public

nephew

nephew侄子, 外甥cousin 1 堂[表]兄弟[姊妹] 2 远亲, 同辈, 同胞 亲戚relativeaunt 1 姑母, 姨母; 伯母, 婶母, 舅母 2 阿姨, 大妈, 大娘 unclen. 伯父, 叔父, 舅父, 姑父, 姨父

a nephew a nephew whose mother is one"s sister

nephew侄子，侄女

爸爸— Father, Daddy, Dad妈妈— Mother, Mummy, Mum哥哥— Brother（缩写是 Bro)嫂嫂— Sister-in-law侄子— Nephew大侄子— Big Nephew小侄子— Small Nephew

http://www.baidu.com/s?lm=0&si=&rn=10&ie=gb2312&ct=1048576&wd=phew&tn=baidu

nephew

Father和mother。

nephewn.侄子，外甥; [英][ˈnefju:][美][ˈnɛfju]Surely no one fires someone who has just done their nephew a good turn?确实没人会解雇一个刚刚对他们侄子有过恩惠的人吗？

family家人father爸爸mother妈妈grandfather外公grandmother外婆uncle叔叔aunt阿姨nephew侄子niece侄女cousin堂兄

答案就是A没错,句子的意思是说这款畅销货,本来打算给她的侄子一个惊喜的,结果却在邮件中弄丢了,填空的地方填的是“本打算的”意思,而畅销货和打算之间是被动关系,所以B和C排除,而这道题并没表现出将要或者伴随的意味,仅仅是对一个事实的陈述,所以不必用D.有什么疑问还可以问我,我一直在线.

叫nephew，外甥

nephew ["nevju(:), "nefju(:)]n.侄子; 外甥[古]孙; 子孙(教士的)私生子

1、nephew英[u02c8nefjuu02d0]、美[u02c8nefjuu02d0] 2、n.侄子; 外甥; 3、[例句]She has a nephew who is just ten years of age她有一个才10岁的侄子。 4、[其他]复数：nephews

外甥

应该就是nephew侄子，外甥顺便告诉你侄女的英文单词：niece希望能帮助你

nephew ["nefjuu02d0; "nevjuu02d0] n. 侄子；外甥 短语 The Nephew 完全因你 ; 亲密访客 ; 侄子 Nephew son 侄女婿 Foreign nephew 外甥 ; 正在翻译 Naughty Nephew 淘气的侄儿 Baby nephew 侄儿小宝贝 ; 宝贝侄子 Nephew relationship 叔侄关系 nephew - 侄子

侄子；外甥

nephew 音节划分：nephu25aaew英 [u02c8nefju:] 美 [u02c8nu025bfju]n.侄子，外甥1. "Cut her out of your will," urged his nephew. “把她从你的遗嘱中删去，”他的侄子催促道。来自柯林斯例句2. She has a nephew who is just ten years of age. 她有一个才10岁的侄子。来自柯林斯例句3. Last month a shopkeeper"s nephew was shot dead. 上个月一名店主的侄子被枪杀了。来自柯林斯例句4. He entrusted the task to his nephew. 他把这任务托付给了他的侄儿。来自《权威词典》

　　存钱罐用来存放钱币的罐子，人们将胖乎乎的小猪存钱罐买给孩子，以培养小孩的理财能力，养成良好的财富观。那么你知道存钱罐用英语怎么说吗?下面我为大家带来存钱罐的英语说法，欢迎大家学习。 　　存钱罐的英语说法1： 　　piggy bank 　　存钱罐的英语说法2： 　　money box 　　存钱罐的英语说法3： 　　Saving pot 　　存钱罐相关英语表达： 　　企鹅存钱罐 Coin Penguin 　　手榴弹存钱罐 Grenade Coin Bank 　　两只小猪存钱罐 two Pyggy Banks 　　存钱罐的英语例句： 　　1. My nephew, George, has a box but it is always empty. 　　我外甥乔治有一个存钱罐,可里面老是空空如也. 　　2. Piggy banks are great as both teaching tools and fun toys. 　　存钱罐就非常好的集教学工具和可爱玩具于一体. 　　3. My nephew, George, has a money box but it is always empty. 　　我的外甥乔治有一个存钱罐,可里面老是空空如也. 　　4. This spiral - shaped piggy bank can be more fun than normal ones. 　　这个螺旋型的存钱罐会比一般的要有趣得多. 　　5. Only very thrifty children managed to fill up a money boxes. 　　只有非常节俭的孩子才会去填满存钱罐. 　　6. Only very thrifty children manage fill up a money - box. 　　只有特别节俭的孩子能把存钱罐填满. 　　7. Students emptied their piggy banks , rummaged pockets, scrounged behind cushions and pitched in leftover lunch money. 　　于是学生们倒存钱罐, 翻口袋, 翻开垫子搜寻,还将吃午饭剩下的钱也投了进来. 　　8. Piggybanks are used by children to save money in. 　　小孩子用猪形储钱罐存钱.

你好！your two times great-nephew你的两次大侄子

口语该用tell：CanyoutellhowoldIam?(bylookingatme的含义)

老Smith是创办人，他的侄子后来加入并继承所以叫史密斯和他侄子。

_gāi〔奇_〕非常；特殊。东西在喉间卡住。笔画数：8；部首：亻；笔顺编号：32415334笔画顺序：撇竖捺横折撇撇捺详解侄_、_zhí【名】弟兄或其他同辈男性亲属的子女〖nephew〗_,兄之女也。从女,至声。《说文》女子谓兄弟之子为_。《尔雅》谓吾姑者,吾谓之_。《仪礼·丧服传》大夫不名世臣_娣。《礼记·曲礼》。疏:“_是妻之兄女。”继室以其_。《左传·襄公二十三年》_其从姑。《左传·僖公十五年》则我皇妣大姜之_。《国语·周语》。注:“女子谓昆弟之子,男女皆曰_。”朱按,受_称者,男女皆可通,而称人_者,必妇人也。男子称兄弟之子曰从子。侄其从姑。《左传·僖公十五年》又如:侄少爷;侄儿;侄儿子;侄哥;表侄;内侄;世侄侄妇zhífù〖nephew"swife〗侄媳妇侄女zhínǚ〖niece〗兄弟或同辈男性的女儿侄女婿zhínǚxu〖niece"shusband〗侄女的丈夫侄孙zhísūn〖grandnephew〗兄弟的孙子侄孙女zhísūnnü〖grandniece〗兄弟的孙女侄外孙zhíwàisūn〖grandnephew〗姐妹的孙子侄外孙女zhíwàisūnnü〖grandniece〗姐妹的孙女侄媳妇zhíxífu〖nephew"swife〗侄子的妻子侄子zhízi〖nephew〗兄弟或同辈男性亲属的儿子出处[①]［gāi］［《__》古哀切，平_，_。］［《__》苦哀切，平_，溪。］［《__》胡改切，上海，匣。］“咳4”的被通假字。非常；不平常。【子集中】【人字部】_；康熙笔画：8；页码：页101第15【__】苦哀切【集_】【__】【正_】柯_切，?音_。【_文】奇_，非常也。【_子·方言】非常曰_事。【_子·_跖篇】_溺於__。【__曰】_食之咽__。__如_河之_，言富人__如_重也。又_胲__?通，皆以兼_立_。又【正_】胡改切，音亥。_同。【卷八】【人部】编号：4954_，[古哀切]，奇_，非常也。从人亥_。

豪欧德阿又？

When the old man heard his nephew"s brave words, which were unyielding and unyielding, he was shocked by the emotion of excitement and pain and could not help crying .

‘Merry Christmas，uncle！God bless you！"cried a happy voice．Scrooge"s nephew had arrived．‘Bah！"said Scrooge crossly．‘Humbug！"‘Christmas is humbug！Surely you don"t mean that， uncle？"said his nephew．‘I do，"said scrooge．‘Why do you call it“merry”Christmas？You"re too poor to be merry．"‘Well，"replied the nephew，smiling，‘why are you so cross？You"re too rich to be unhappy．"‘of course I"m cross，"answered the uncle，‘when I live in a world full of stupid people like you！You say“Merry Christmas”！But what is Christmas？Just a time when you spend too much，when you find yourself a year older and not an hour richer，when you have to pay your bills．Everyone who goes around saying“Merry Christmas”should have his tongue cut out．Yes，he should！"‘Uncle！Please don"t say that！"said the nephew．‘I"ve always thought of Christmas as a time to be helpful and kind to other People．It"s the only time of the year when men and women open their hearts freely to each other．And so，uncle， although I"ve never made any money from it，I think Christmas has been and will be a good time for me！And I say，God bless Christmas！"Bob，in the cupboard，agreed loudly，without thinking．He immediately realized his mistake，and went quickly back to his work，but Scrooge had heard him．‘If I hear another sound from you，"said Scrooge，‘you"ll lose you job！"‘Don"t be angry with him，uncle，"said the nephew．‘come and have dinner with us tomorrow．"‘Dinner with you？I"ll see you dead first！"‘But why won"t you come？Why？"‘Because Christmas is humbug！Good afternoon！"‘I want nothing from you．I ask nothing of you．Why can"t we be friends？"‘Good afternoon！"said Scrooge．‘I am sorry，with all my heart，to find you like this．I have never wanted to argue with you．But I came to see you and invite you because it"s Christmas，and so I"ll say，a merry Christmas，uncle！"‘Good afternoon，"said Scrooge．‘And a happy new year！"‘Good afternoon！"said Scrooge．His nephew left the room，without an angry word，stopping only to wish Bob Cratchit a merry Christmas．Then two other gentlemen came in．They were large，round，comfortable-looking men，with books and papers in their hands．‘This is Scrooge and Marley"s，I think，"said one of them， looking at the papers that he was carrying．‘Am I speaking to Mr Scrooge or Mr Marley？"‘Mr Marley is dead，"scrooge replied．‘He died seven years ago today，on Christmas Eve．"‘I"m sure that you are just as kind to the poor as your partner，"said the gentleman，smiling．What was true was that Scrooge was just as mean as Marley，and Marley had been just as mean as Scrooge．‘At this happy time of year，Mr Scrooge，"the gentleman went on，taking up his pen，‘we should help poor people who have no food or clothes or homes．"‘Are there no prisons？"asked Scrooge coldly．‘Plenty of prisons，"said the gentleman．‘And the workhouses，where poor people can live and work？Are they still open？"‘Yes，they are，I"m sorry to say．"‘I"m happy to hear It，"said Scrooge．‘I thought，from what you said at first，that perhaps these useful places were closed，for some reason．"‘But some of us feel，"replied the gentleman，‘that these places don"t offer enough to poor people．We"re hoping to give some meat and drink，and wood for a fire，to people who need all these things．This is a time when we should all be able to enjoy ourselves．How much will you give，sir？"‘Nothing！"scrooge replied．‘I don"t have a merry Christmas myself，and I won"t pay for other people to be merry．We all have to pay for prisons and workhouses—they cost enough．The poor will have to go there．"‘Many can"t go there，and many prefer to die．"‘If they prefer to die，why don"t they die，then？There are too many people in the world，so it"s a good thing if some of them die．All this is none of my business！It"s enough for a man to understand his own business，and not to think about other people"s．I"m a very busy man．Good afternoon，gentlemen！"The gentlemen shook their heads a little sadly，and left the office．Scrooge went back to his work，feeling pleased with himself．Now the fog was at its thickest outside，and the cold was biting．Lights shone brightly from the shop windows．People were hurrying here and there—rich and poor alike－to buy what they needed for tomorrow"s Christmas dinner．At last it was time to close the office．Scrooge got up slowly from his desk．Bob was waiting for this moment，and he immediately put on his hat．‘You"ll want a holiday all day tomorrow，I suppose？"said Scrooge．‘If you don"t mind，sir．"‘I do mind．It"s not fair．I have to pay you for a day"s work when you don"t do any work．"‘It"s only once a year，sir，"said Bob politely．‘That"s no reason for robbing me every twenty-fifth of December！"said Scrooge，putting on his coat．‘But I suppose you must have it．Be here early next morning．"‘Yes，sir，I will，I promise，"Bob said happily．Scrooge walked out，without another word．When bob had closed the office，he ran home to his family in Camden Town as quickly as possible．Scrooge always used to eat his dinner alone，in the same miserable little eating-house．Tonight was no different from other nights．He read the newspapers，looked at his bank books， and went home to bed．He lived in rooms which had once belonged to his dead partner．They were in an old，dark building in a lonely side street，where no one except Scrooge lived．In the blackness of the night，through the fog and the frost， Scrooge had to feel his way along the street with his hands．He finally reached his front door and put the key in the lock．Suddenly，to his great surprise，he saw that the knocker was not a knocker any more，but had become the face of Jacob Marley！He had not thought of his partner for seven years，until that afternoon，when he spoke Marley"s name to his visitors．But there in front of him was Marley"s face，white and ghostly， with terrible staring eyes．As Scrooge looked，it became a knocker again．He was afraid，but he did not show his fear．He turned the key， opened the door and walked in．He did look around before he shut the door，and he did look behind the door，to see if anyone was hiding there．But there was nothing there．He shut the door with a bang，to show that he was not afraid．With his one candle he went slowly up the stairs．It was impossible to see into all the dark corners．Darkness was cheap， and Scrooge liked it．But he remembered the face，so he walked through all his rooms，checking that everything was all right．Nobody under the table or the bed，nobody behind the door！On the small fire in the bedroom there was a pot of soup，and Scrooge"s bowl was ready on the table．Nobody in any of the rooms！Sure that he was safe now，Scrooge shut and locked his bedroom door behind him．He sat down by the fire to eat his soup．The fireplace was an old one，with hundreds of pictures on the tiles around the fire．But Scrooge could only see Marley"s face on every tile．‘Humbug！"said Scrooge to the tiles，and walked across the room．When he sat down again，he noticed a bell on the other side of the room．As he looked，he saw，with great surprise and fear，that the bell was slowly beginning to move from side to side．Soon it was ringing loudly，and so was every bell in the house．Suddenly they all stopped ringing at the same moment，and then came a strange noise from down below．It sounded like someone pulling heavy chains across the floor．Scrooge remembered hearing that ghosts in old houses sometimes pulled chains behind them．Then a door below opened with a crash，and the noise started coming up the stairs．It was coming towards his door．‘It"s humbug still！"cried Scrooge．But the colour left his face when，without stopping，it came straight through the heavy，locked door，and appeared in front of him．It was Marley"s ghost！Scrooge could see right through its body．Around its middle was a long chain，which had money-boxes，keys，bank books， and heavy purses on it．The ghost"s death-cold eyes stared fixedly at Scrooge．‘Well！"said Scrooge，trying to pretend that nothing strange was happening．‘What do you want？And who are you？"‘In life I was your partner，Jacob Marley．"‘It"s humbug，I tell you！"said Scrooge．‘There are no ghosts！"But when he said this，the ghost gave a terrible cry， and shook its chain in a very frightening way．At once Scrooge fell on the ground in great fear，crying，‘Yes！Yes！You are real！I see that now！Why have you come？Why do ghosts come back from the dead？Tell me，Jacob！"‘The spirit of every man who does not help other people in life has to travel endlessly through the world after his death．We have to carry the chains that we made for ourselves in our lifetime．Do you，Ebenezer Scrooge，recognize my chain？It is very like the one that you wear！"Scrooge looked around him，but could see no chain．‘Jacob，"he said，‘please tell me more！"‘I cannot help you much，Ebenezer！I cannot rest，I cannot stay anywhere for long．I have been dead for seven years and all that time I have been travelling on the wings of the wind！ No peace，no rest for me in death，because I was never good or kind in life！"‘But you were always a good man of business，Jacob，"said Scrooge，who was now beginning to worry about his own life．‘Business！"cried the ghost miserably．‘Why didn"t I think of people as my business？I thought only about making money，not about being kind and helpful to other people．Listen to me，Ebenezer！I am here tonight to warn you．You still have a chance to save yourself from what has happened to me．Three spirtis will come to visit you：the first tomorrow at one o"clock，the second at the same time the next night，and the third at midnight the following night．You will not see me any more，and for your own peace after death，remember what I have told you！"

上面的如果不是用翻译网的话...那好厉害噢...我觉的第一篇不错.

不能，who要紧跟the boy ，否则不通顺

可以填hanging或hung.不能填hangs.hang有悬挂,绞死的意思,是有被动语态的.只不过hang表悬挂时,过去式过去分词都为hung,表绞死时过去式和过去分词为hanged

1. 侄字怎么组词 侄 拼音： zhí 笔划： 8 部首： 亻 五笔输入法： wgcf 弟兄的儿子，同辈男性亲友的儿子：侄儿。侄女。叔侄。子侄辈。侄孙。 brother"s sonnephew 详细解释： 侄 侄、妷 zhí 【名】 （侄为侄的俗字）弟兄或其他同辈男性亲属的子女〖nephew〗 侄，兄之女也。从女，至声。——《说文》 女子谓兄弟之子为侄。——《尔雅》 谓吾姑者，吾谓之侄。——《仪礼·丧服传》 大夫不名世臣侄娣。——《礼记·曲礼》。疏：“侄是妻之兄女。” 继室以其侄。——《左传·襄公二十三年》 侄其从姑。——《左传·僖公十五年》 则我皇妣大姜之侄。——《国语·周语》。注：“女子谓昆弟之子，男女皆曰侄。”朱按，受侄称者，男女皆可通，而称人侄者，必妇人也。男子称兄弟之子曰从子。 侄其从姑。——《左传·僖公十五年》 又如：侄少爷（旧时对侄子的尊称）；侄儿（侄子）；侄儿子（侄儿，侄子）；侄哥（对侄子的爱称）；表侄；内侄；世侄 侄妇 zhífù 〖nephew"swife〗侄媳妇 侄女 zhínǚ 〖niece〗兄弟或同辈男性的女儿 侄女婿 zhínǚxu 〖niece"shu *** and〗侄女的丈夫 侄孙 zhísūn 〖grandnephew〗兄弟的孙子 侄孙女 zhísūnnü 〖grandniece〗兄弟的孙女 侄外孙 zhíwàisūn 〖grandnephew〗姐妹的孙子 侄外孙女 zhíwàisūnnü 〖grandniece〗姐妹的孙女 侄媳妇 zhíxífu 〖nephew"swife〗侄子的妻子 侄子 zhízi 〖nephew〗兄弟或同辈男性亲属的儿子 相关词语： 子侄 宗侄 侄女 侄妇 侄媳妇 侄娣 侄兽 侄外孙 侄男 侄哥 侄女儿 族侄 侄儿子 侄孙女 侄外孙女 侄孙妇 侄子 侄女婿 侄孙 侄儿 侄儿媳妇 侄少爷 再从侄 淫侄 小侄 乡侄 贤侄 甥侄 表侄 表侄女 从侄 从表侄 弟男子侄 娣侄 孤侄 皇侄 门侄 内侄 内侄女 年侄 女侄 2. 侄字组词有哪些 侄字组词有哪些 ： 侄子、 子侄、 侄女、 侄妇、 侄孙、 侄兽、 从侄、 侄儿、 族侄、 宗侄、 甥侄、 贤侄、 蠪侄、 年侄、 女侄、 侄哥、 孤侄、 娣侄、 门侄、 皇侄、 小侄、 乡侄、 侄娣、 侄男、 阿侄、 内侄女、 侄媳妇、 表侄女、 侄女婿、 侄外孙、 再从侄、 侄儿子、 侄女壻、 侄孙妇、 侄少爷、 从表侄、 侄女儿、 侄儿媳妇、 弟男子侄、 侄外孙女

d过去分词做定语表示被动

The picture "that is hanging" on the wall is painted by my nephew.

玩傻了吧。。

　　靶向治疗为肿瘤治疗带来了新的革命，将成为本世纪肿瘤治疗中最具潜力、最有希望的疗法。下面是我推荐给大家的，供大家参考。 　　一、EGFR突变 　　EGFR***英语：epidermal growth factor receptor，简称为EGFR、ErbB-1或HER1***是表皮生长因子受体***HER***家族成员之一。该家族包括HER1***erbB1，EGFR***、HER2***erbB2，NEU***、HER3***erbB3***及HER4***erbB4***。HER家族在细胞生理过程中发挥重要的调节作用。 　　EGFR基因在亚裔腺癌人群中的突变频率是10%-40%，常见突变位点：19外显子缺失突变，21外显子L858R点突变及18与20外显子突变等。 　　一代易瑞沙、特罗凯、凯美纳靶向的出世，创造了肺癌治疗史上的奇迹。后续抑制作用较强的二代不可逆抑制剂阿法替尼也进入大家视野，阿法替尼是靶向EGFR及HER2的双靶点抑制剂，疗效肯定，但国人的不良反应相对多些。而一代二代药物治疗在一年左右的时间会出现不同程度的耐药，在对于耐药机制的研究中发现了T790M的二次突变，针对于此的三代EGFR-TKI抑制剂AZD9291也因此普及，形成了目前三代EGR-TKI的治疗阶梯。我们也要认识到国内上市的靶向药物只有一代的易瑞沙，特罗凯，凯美纳，二代药物阿法替尼即将上市，三代药物也只有临床试验，基于药物未在中国上市，病情进展后可以进行化疗。 　　二、ALK融合或重排 　　ALK融合或重排在肺腺癌中占5%-10%，其常见的融合方式是EML4-ALK。其靶向的一代药物是国内已有的克唑替尼，可产生74%的有效率。而长期使用的患者也会在中位1-2年时间出现耐药，即发生ALK守门基因的突变导致继发耐药，从而促发了二代甚至是三代药物的出现，也形成了ALK治疗的三阶梯，但国内上市的ALK靶向药物只有克唑替尼一种，化疗仍是ALK耐药后的选择。 　　三、ROS1的融合 　　ROS1的融合在肺腺癌中突变率较低，1.2%--1.7%，常见于年轻、非吸菸、腺癌、高级别组织病理型别患者。这一基因融合与ALK类似，具有明确的肿瘤形成驱动性及较好的临床疗效。因此2017.2版NCCN指南中首次将ROS1提到肺腺癌的常规检测中，制定了该类患者特定的临床治疗路径。 　　对于ROS1重排阳性的患者，一线初试治疗推荐克唑替尼用药，有效率可达到72% ，耐药时间19.2 月，病情进展后可以进行化疗或PD-1的免疫治疗。 　　肺癌的免疫治疗 　　1、抗体靶向的免疫治疗在很多恶性肿瘤上已获得早期成功，在晚期肺癌和其它肿瘤的治疗中已经起到了很大的作用。 　　2、一些靶向PD-1受体的单克隆抗体***nivolumab, pembrolizumab*** 或其配体PD-L1 ***atezolizumab, durvalumab, avelumab***已应用于临床。这些药物的早期临床试验已证实在经治疗的晚期NSCLC患者中，14-20%表现出迅速且持久的反应，且生存率的改善显著。最主要的副作用是无力、疲劳、丧失食欲、恶心及腹泻。 　　3、抗PD-1或抗PD-L1药物的临床疗效及安全性被4个随机临床试验支援，其中有代表性的2个是在经基于铂类化疗治疗的患者中比较nivolumab与多西他赛治疗效果--CheckMate 017试验和CheckMate 057试验。 　　4、检查点抑制剂的获益主要限于PD-L1阳性肿瘤人群。Pembrolizumab在PD-L1表达细胞数≥50%的情况下，已被FDA批准作为二线及以上线的治疗。默克公司宣布一项达到终点的大型研究表明，在PD-L1表达细胞数≥50%的情况下，pembrolizumab与化疗相比，PFS和OS获益明显。在一项包含所有NSCLC组织学亚型的II期试验中，atezolizumab与多西他赛相比，表现出明显获益。 　　5、整体的资料表明PD-1抑制剂倾向于在经过标准化疗的肺鳞癌中作为二线治疗，在非肺鳞癌中至少需要满足PD-L1阳性的条件。 　　6、在之前未经治疗的患者中，抗PD-1或抗PD-L1抑制剂的早期试验的结果喜人--在PD-L1阳性患者中1年生存期超过70%。几项试验正在比较这些药物联合铂类治疗方案作为一线治疗的效果。 　　肺癌的症状 　　1、咯血 　　气管，支气管和肺组织出血，经口腔咯出称为咯血，咯血量的多少视病因或病变的性质而异。 　　2、呼吸异常 　　人呼吸频率成人为16~20次/min，与心脏搏动次数的比例为1：4。 　　3、痰有恶臭味 　　痰的气味呈恶臭味时，肺部炎症伴有厌氧菌感染。见于肺脓肿、支气管扩张及肺的恶性肿瘤晚期等肺部疾病。 　　4、鼠尾征 　　鼠尾征指支气管肺癌沿支气管的纵轴浸润蔓延，使支气管呈尾巴状狭窄且不规则的缺损。

ESB 站在更高的位置，它的组成部件是 EJB，当一个请求进来，会按某个我们的查找到一个服务器去调用EJB，这些 EJB 都提供 web service 接口展示给服务器。

这个不太懂，你问问专业人士吧

歌曲名:Smells Like Teen Spirit歌手:Nirvana专辑:From The Muddy Banks Of The WishkahNirvanaSmells Like Teen SpiritLoad up on guns and Bring your friendsIt"s fun to lose And to pretendShe"s over bored And self assuredOh no, I know A dirty wordhello, how low? (x bunch of times)With the lights out it"s less dangerousHere we are now Entertain usI feel stupid and contagiousHere we are now Entertain usA mulatto An albinoA mosquito My LibidoYeahI"m worse at what I do bestAnd for this gift I feel blessedOur little group has always beenAnd always will until the endhello, how low? (x bunch of times)With the lights out it"s less dangerousHere we are now Entertain usI feel stupid and contagiousHere we are now Entertain usA mulatto An albinoA mosquito My LibidoYeahAnd I forget Just why I tasteOh yeah, I guess it makes me smileI found it hard It was hard to findOh well, whatever, nevermindhello, how low? (x bunch of times)With the lights out it"s less dangerousHere we are now Entertain usI feel stupid and contagiousHere we are now Entertain usA mulatto An albinoA mosquito My LibidoYeah, a denialA denialA denial...http://music.baidu.com/song/7550698