- 豆豆staR
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The cornerstone of Windows 2000 security is Active Directory.
Windows 2000 的安全保障基础是活跃的根目录。
Its support for granular access control, inheritance, and delegation of administrative task gives you the flexibility to secure resources without compromising your network"s purpose.
它支持管理任务的粒状通路控制、继承和授权,使用户能灵活保护资源而不会泄露计算机网络目的。
The essence of a type is that it attempts to identify qualities common to a group of individuals or objects that distinguish it as an identifiable class or kind.
类型的本质是它尝试识别对个体群或者将它作为一个可以确认的级别或类型来区别的物体的质量。
Court decisions, however, seem to support the notion that because an organization owns and operates an e-mail system, the e-mail messages are also the property of the organization.
然而,追求判决, 似乎支持这一观念“因为一个组织拥有且操作一个电子邮件系统,电子邮件信息也同样是组织的财产。”
With a plug-and-play system, users can install devices into or remove them from a desktop or mobile PC; dock and undock desktop PCs from a network; and optimally configure the system for different applications without modifying configuration parameters or expansion-card jumper settings
藉由一个即插即用系统,使用者能在一个桌面或可动装置个人计算机上安装或卸载装置; 从计算机网络上安装或卸载桌面个人计算机; 而且在没有修正结构叁数或扩充-卡片的跳跃者设定配置系统的情况下从最佳的角度确认出系统的不同申请。
In some ways, it is analogues to a telephone switch-board with intelligence because it makes the connections between various functional units of the computer system and calls into operation each unit that is required by the program currently in operation.
从某些方面来看,一个电话开关是智力的模拟物因为它使各种不同的计算机系统单元和呼叫连结入对每一个当前运作中的程序所需求的单位的操作。
The main difference between a communication path established using a LAN and a connection made through a public data network is that a LAN normally offers much higher data transmission rates because of the relatively short physical separations involved.
使用区域网络建立的沟通路径和通过公共数据网络建立的连接的区别在于:区域网络的转换率更高。因为它涉及的物理分区相对较短。
A function test evaluates the system to determine if the functions described by the requirements specification are actually performed by the integrated system.
一个功能测试评估系统决定由需求特征所描述的功能是否确实有整个系统来操作。
Depending on the machine being used, a UNIX system can support from one to over one hundred users, each concurrently running a different set of programs.
依靠当前所用的机器, UNIX 系统能支援从一到在上百使用者, 每个UNIX系统都能同时地运行一套不同的操作。
The cost of a computer that can be used by many person at the same time is less per user than that of a computer can be used by only a single person at a time.
一台能同时被多人使用的计算机的每单位用户耗能比一台只能有一人单独操作的计算机的每单位用户耗能更少。
Given the relative quickness of software development, one would think that software solutions would lead the computing agenda for many years. But as software delays have become more profound and commonplace, hardware-featured solutions are beginning to offer better solutions than their software counterparts.
假设有了相对较快的软件发展,可以认为软件解决方案将引领多年的计算机日程。但是由于软件的慢速发展的问题变得更为深奥并成为了老生常谈,硬件特征解决方案于是乎成为了比软件提供了更好的解决方案。
And given the improving capabilities of hardware development, hardware vendors will become the clear leader in this race.
有了硬件发展的改善能力的保障,硬件卖家将成为这一领域的领头羊。
(。。。。。终于翻好了。。。绝对人工翻译!历时两个小时,正确率98%)
- FinCloud
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窗口 2000 安全的基石是活跃的目录。 它对管理工作的粒状通路控制、遗传和代表团的支持给你柔性没有妥协处理你网络的目的巩固资源。
类型的本质是它尝试识别对一群个体或者区别它作为一个可以确认的班级或类型的物体是通常的质量。
然而,追求判决, 似乎支援观念因为一个组织拥有而且操作一个电子邮件系统,电子邮件信息也是组织的财产。
藉由一个即插即用系统,使用者能安装装置进入或者把他们从一个桌面或可动装置个人计算机移开; 来自一个网络的码头和出坞桌面个人计算机; 而且最佳地为不同的申请没有修正结构叁数或扩充-卡片的跳跃者设定配置系统
在一些方法中,它是对一个电话开关的类似物-以智力搭乘因为它使各种不同功能单位的计算机系统和呼叫之间的连结成为在运转现在被计画需要的操作每个单位。
主要的不同在沟通路径之间建立使用一个区域网络,而且做过一个公众的数据网络的一个连接是评估的一个区域网络通常提供非常高的数据传输因为那相对地短身体的分离牵涉。
一个功能测试评估系统决定是否被需求规格描述的功能实际上被整合系统运行。
仰赖被用的机器, UNIX 系统能支援从一到在一百使用者之上 , 每个协同地跑一不同组的计画。 那能同时被被许多人用的计算机花费超过计算机的每一使用者是比较少量能是每次被只有一个人用。
如有软件发展的亲戚急速,一会认为软件解决会带领计算机议程许多年。但是当做软件延迟已经变得更极深和更平凡又硬件扮演重要角色的解决正在开始超过他们的软件对方提供较好的解决。 而且提供硬件发展的改良能力, 硬件厂商将会在这一个比赛中成为清楚的领袖。
- 里论外几
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基石的Windows 2000安全是Active Directory的。它支持细粒度的访问控制,继承和下放的行政工作,让你的灵活性,以确保资源又不损害你的网络的目的。
精髓一类是,它试图找出共同特质的一组个人或物体区分开来,它作为一个可识别的阶级或实物。
法院的判决,但是,似乎支持这一概念,因为一个组织拥有并经营一个电子信箱系统,电子邮件讯息,也是本组织的财产。
一个即插即用式系统,用户可以安装一些装置投入或移除他们从台式电脑或手提电脑;船坞和undock台式电脑,从网络和最佳配置系统不同的应用程序无需修改配置参数或扩充卡跳线设置
在某些方面,它的类似物,以一个电话交换机局与情报,因为它使之间的联系,各功能单位的电脑系统,并呼吁到行动中,每个单位须根据计划,目前在运作。
二者的主要区别通信路径建立了利用局域网,并提供一个连接通过公共数据网是一个局域网,通常提供更高的数据传输速率,因为相对较短的物理分离。
功能测试评估系统,以确定是否所述职能所要求的规格,有事实上是通过综合系统。
依靠机器被利用, UNIX系统能够支持从一个超过100用户,每个同时运行另一套不同的节目。成本,一台计算机可用于许多人在同一时间,那么每个用户比一台计算机可以使用的只有一个单一的人在一段时间。
由于相对快速的软件开发,一会认为软件解决方案,将导致计算议程多年。但由于软件延误变得更加深刻和普遍,硬体特色解决方案已开始提供更好的解决方案,比他们的软件。并考虑到提高能力的硬件开发,硬件厂商将成为明显的领先者,在这项赛事。
- cloudcone
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除了1100的那个,其它全是不要脸拿软件翻的。要混分直接说一声还比较好。
楼主,1100的那个翻译的可以,我浏览了。你选她的吧。
- 瑞瑞爱吃桃
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太长了,估计200分才会有人愿意翻。
- 贝贝
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视窗2000 安全基石是活跃目录。它的支持对于颗粒状存取控制、行政任务的继承, 和代表团给您灵活性巩固资源没有减弱您的网络的目的。 型的精华是, 它试图辨认质量共同对区别它作为可识别的类或种类的一个小组个体或对象。 判决, 然而, 似乎支持的概念因为组织拥有和操作电子邮件系统, 电子邮件并且是组织的物产。以插座和戏剧系统, 用户能安装设备入或从桌面或流动个人计算机去除他们; 靠码头和把桌面个人计算机驶出船坞从网络; 并且优选地配置系统为不同的应用没有修改配置参量或扩展卡片套头衫设置 在一些方面, 这是类似物对一台电话交换机以智力因为它建立联系在计算机系统的各种各样的功能部件之间和叫入操作由节目当前必需运转中的各个单位。主要区别在通信通道建立使用LAN 和联系之间被建立通过公开数据网络是, LAN 通常提供更高的数据传输率由于相对地短的物理介入的分离。功能考验评估系统确定如果作用由要求规范描述由集成系统实际上执行。 根据机器被使用, UNIX 系统可能支持从一个对一百名用户, 每个一致地运行另外套节目。可能由许多使用人同时是较少每用户一台计算机的费用比那计算机可能由唯一一个唯一人使用一次。 假使软件开发的相对快速, 你会认为, 软件解答会带领计算的议程许多年。但是当软件延迟变得更加深刻和普遍, 硬件特色的解答开始提供更好的解答比他们的软件相对物。并且给硬件发展的改善的能力, 硬件推销员将成为清楚的领导在这种族。
analogues是什么意思
意思是类似物2023-07-30 04:42:311
analogous analogue的区别
(Oxford Advanced English Dictionary 6th edition)analogous adjective(formal) ~ (to / with sth) similar in some way to another thing or situation and therefore able to be compared with it: Sleep has often been thought of as being in some way analogous to death. ◆ The two processes are not analogous.analogue (BrE) (AmE analog) adjective, noun adjective (technical) (of an electronic process) using a continuously changing range of physical quantities to measure or store data: an analogue circuit / computer / signal (BrE also analog) (of a clock or watch) showing the time using hands on a DIAL and not with a display of numbersCompare: DIGITAL noun (formal or technical) a thing that is similar to another thing: Scientists are attempting to compare features of extinct animals with living analogues.2023-07-30 04:42:413
Analogue (All I Want) 歌词
歌曲名:Analogue (All I Want)歌手:A-Ha专辑:AnalogueStrung Out - Analog---by 汲雪寒舟---Through the coolest hazeOf this dreamlike mazeIt has begunAnd all I wanted you nearWith these wounds I bledA perfect tone of redIn isolationThrough the swollen eyesOf the dying, and my waking dreamsWe"re all dying to become what we swore we never wouldNow I watch and mourn in bloomYou take the way you knowI"ll take the road unknownAnd meet you thereAt the end of timeWe are frequencyWe are tragedyWe are the loveWe need to keep us hereWe are the dying, we are the hungry onesWe are the waiting forever faithfulWhen I see you on the other sideI will not be the sameAs I was when I was yoursHow I wanted you nearWe are the dying, we are the lonely onesWe are the heartache forever waitingWhen I see you on the other sideI will not be the sameAs I was when I was yoursWe"ve got the anger, fear and isolation,Exiled to this place.We"ve got the pain, separates the tragic yearsI"ve gone through all this wasteAnd when we finally separate ourselvesThe world we choose to leave behindI will not be the sameAs I was when I was yourshttp://music.baidu.com/song/75252742023-07-30 04:42:481
卡瓦列利原理的原理平面
其实就是祖暅原理,其实最早还是刘徽提出来的,祖暅用这个原理求解了刘徽为了求球体积而提出的牟合方盖的体积,间接求出了球的体积,很八卦~~不多说啦,其实原理很简单,就是如果两个等高的三维立体的每个截面的面积比相同,那么这两个立体的体积之比即每个面的面积之比,每个等高截面称之为卡瓦列利原理的原理平面,其实用极限的思维很好理解,你不懂再问啊~~给分吧2023-07-30 04:42:562
碱基类似物(base analogues)
【答案】:一种与DNA正常碱基结构类似的化合物如5-溴尿嘧啶、5-氟尿嘧啶、2-氨基腺嘌呤。其进入细胞后能替代正常碱基掺入到DNA链中而干扰DNA复制合成。这些类似物易发生互变异构,在复制时改变配对的碱基,引起碱基对的突变,属于致癌物质。2023-07-30 04:43:101
这个怎么翻译啊
其馀PZ轨道上每三个相邻的碳碳重叠,形成一个带称为价带填充π轨道,并带一个空π*轨道,称为导带。虽然每个碳表格上的四个价电子三个σ(单)的粘,第四电子形式同其邻国之一和三分之一的生产石墨的碳 - 碳键的顺序,每个π键的三分之一。与没有在c方向的化学键,平面的相互作用极其微弱。这包括充电和热载体的传播,这导致平面电气和热导率双双超过103次低於他们在飞机analogues.56(瑰珀翠的催化剂)2023-07-30 04:43:213
浅谈语言谱系分类和类型分类
同样的事物可以按照不同的分类方法将其分出不同的类别,例如人,我们可以按照性别分为男人女人两种,可以按照年龄分为婴幼儿、儿童、少年、青年、中年、老年等,也可以按照职业进行划分,那就太多了。而世界的语言,为了更好的进行研究,专家学者们也将其进行了分类,而现在最主要的分类方法有谱系分类法和类型分类法两种。 世界语言的分类研究起源于欧洲,其中谱系法根据亲属关系、类型法根据同型性划分语言类别。 语言的谱系分类法也叫“发生学分类法”,是德国语言学家奥古斯特·施莱谢尔(August Schleicher)提出来的。他受达尔文的进化论的影响,发明了一种按照植物分类法则对语言进行谱系分类,并按照生物进化树的方式排列各种语言。他提出了语言进化的概念,绘制了语言学里的第一棵谱系树。 对语言的谱系分类,有点类似在一个族群中划分族谱。将每一种语言看做是语言大家庭中的一员,那么若干种语言就存在一个共同的祖先,于是语言学家们就虚拟出了语言学上关于祖语的概念。 祖语(proto-language),又称原始语、原语。指某个语言家族(如语系、语族、语支)的共同祖先,即其一脉相承的古代语言。 语言的分类不像自然科学领域中的分类那样具有刚性,不同的学者有不同的分类标准,但学者们大致按照语门>语系>语族>语支>语言>方言的层级对语言进行系属分类。当然这是很粗略的,目前已被认定的语言系属有上百种,全世界现存的语言约7000种。显而易见,人类肯定是先有口头语言后有文字,人类的先祖们说的是什么口语我们是没办法知道的,故语言系属分类是依据各语言的语音、词汇、语法之间的对应特征推演而来。 下文就对语言系属分类各层级的概念作一个简要的介绍。 一、语门 语门(Language phylum)是语言分类学的一个专属名词,借用了生物学上“门”(phylum)的概念。一般来说,语门都是用来指一些跨越多个语系的语言关系,过去又称为超语系。 现时在语言学专业里提出过的语门有以下几个: 1、亚非语门(Afroasiatic language phylum) 2、南方语门(Austronesian language phylum)Aztec-Tanoan language phylum 3、德内-叶尼塞语门(Dené-Yenesian language phylum) 4、欧亚语门(Eurasiatic language phylum)Hokan language phylum 5、中美州语门(Mesoamerican language phylum) 6、纳-德内语门(Na-Dené language phylum) Penutianlanguage phylum 语门的分类及研究工作是在20世纪末期才开始的,在古老的语言学中,这是一个很新的课题,因此目前存在着较大的争议,通俗些讲就是还不成熟。但为了语言学科知识体系的完善,这是一个有价值的研究方向。 二、语系 语门的下一级分类是语系。在世界语言学界,学者们对语系的分类各自有不同的见解,之间存在着或大或小的差异。这里我们介绍国内学者采用较多的12个语系: 1、汉藏语系(Sino-Tibetan) 以汉藏语系为母语的人口占世界人口的五分之一以上。分布较为集中,以东亚的中国为中心,略向西南辐射。 2、印欧语系(Indo-European) 印欧语系拥有最多的母语人口,是世界上影响力最大,语族最多的语系。地理分布跨度大,范围广。 3、高加索语系(Caucasian languages) 高加索语系分布在位于黑海和里海间的高加索地区和伊朗、土耳其部分地区。(有时高加索诸语被错误地称为是“高加索语系”。其实它们之间几乎没有明显的亲和力。) 4、乌拉尔语系(Uralic languages) 乌拉尔语系是分布于从斯堪的纳维亚往东经乌拉尔山脉到亚洲西北部广大地区的一组语言 。 5、阿尔泰语系(Altaic languages) 阿尔泰诸语是语言学家按照语言系属分类(谱系分类法)方法划分的一组语言,包括了60多种语言。所谓“阿尔泰语系”已经是一个过时的概念。主要分布在中亚、北亚。 6、达罗毗荼语系(Dravidian family) 达罗毗荼语系分布于印度半岛中南部,又名德拉维达语系,斯里兰卡北部和巴基斯坦等地, 7、南亚语系 (Austroasiatic languages) 南亚语系主要分布于中南半岛。约有168种语言被划分在南亚语系,分布在印度、孟加拉、尼泊尔和中国南部边境。 8、南岛语系(Austronesian languages) 南岛语系是主要由南岛民族所使用的语言,是世界现今唯一主要分布在岛屿上的一个语系,包括约1300种语言。其分布东达南美洲西方的复活节岛,西到东非洲外海的马达加斯加岛,南达新西兰,北至台湾岛。其东西的延伸距离超过地球圆周的一半。 9、闪含语系(Semito-Hamitic languages) 闪含语系Hamito-Semitic family(闪米特-含米特语系),又称亚非语系(Afro-asiatic languages)。圣经说,挪亚的儿子闪是希伯来人的祖先,儿子含是亚述人和非洲人的祖先 ,故称闪含。主要分布在北非到非洲之角、西南亚。 10、尼日尔-科尔多凡语系(Niger-Kordofanian family) 尼日尔-科尔多凡语系是非洲最大的语系。主要是分布于非洲西部的塞内加尔地区,经过上几内亚高原区到东部的肯尼亚,向南到大陆南端好望角,大概有900种语言。此语系中的所有语言已被语言学家归类为尼日尔-刚果语系语言。 11、尼罗-撒哈拉语系(Nilo-Saharan languages) 尼罗-撒哈拉语系分布于非洲的尼罗河沿岸,尼日尔河沿岸以及非洲中部的撒哈拉地区,包括了中苏丹语族、东苏丹语族、撒哈拉语族、桑海语族、马巴语族等语族。 12、科依桑语系(Khoisan family) 科依桑语系是霍屯督人和布须曼人以及非洲南部其他非班图人使用的一组语言。 三、语族、语支、语言、方言 语族、语支、语言及方言都是语言谱系分类法的单位,它们之间的关系上文已经介绍过了。世界语言有7000多种,如果我们从语族开始往下介绍,那是一个很大的体系网络。本文的主题是对语言的分类进行一个简述。为了便于说明和使读者易于理解,笔者将汉藏语系语族、语支、语言及方言大致情况用表格说明: 这里要说明的是: 第一、语言的谱系分类是以语言的亲属关系为依据的,然而这种亲属关系主要依靠研究者的分析推论得来,并无一个硬性的标准,不同学者间的差异是很大的。 第二、汉语自古以来是在一个相对比较孤立的环境下发展而来的,虽然与周边少数民族语言有过许多的交流和融合,多数情况是同化为一体,尤其汉语体系在统一文字的作用下,虽不同区域之间口语往往不能交流,但书面语是可以流畅沟通的。因此汉语在汉藏语系中分出汉语语族后,就没派生出不同的语支。汉语不同区域的变体,应该列为不同的语言还是方言,学者们有较大的分歧,但目前更多倾向于列为方言,即汉语从语族往后,没有不同的语支和语言,只有不同的方言。 类型分类法,又称结构分类法。 1772年,Diderot和d"Alembert在他们编纂的法国《百科全书》中,在“语言”条下,作者根据语言的语法结构总特点,区分了两种基本的语言类型:类推型语言(langues analogues和换位型语言(langues transpositives)。然而这种二分法在某些方面含混不清,过于粗线条。十九世纪初期,A.W.von schlegle提出:“我们地球上不同民族以前和今天所说的语言,可以分为三类:没有任何语法结构的语言、使用词级的语言和具有屈折变化的语言。”即为大家现在所熟知的三重类型分类法,语言分成孤立型、粘着型和屈折型。这是一个非历史的分类系统。 现代语言学根据语言的共同形态结构对世界上的语言进行分类,即语言的形态分类(morphological typology),按照这种方法根据语言组合语素栬单词的方式,将语言分为“分析语”和“综合语”两类。 分析语和孤立语之间的概念有时并不很清晰,它们之间的关系常会出现两种情况,其一是将孤立语与分析语两者视为相同的概念;其二是将孤立语纳入分析语,将孤立语视为分析语最极端的表现。而综合语又细分为黏着语、屈折语和多式综合语三种。 下面笔者通过几个例子简略地介绍一下这几个概念: 1、孤立语,代表:汉语 孤立语的特点在于其一般不是通过词形变化来表达语法的作用,而是通过独立的虚词和固定的词序来表达语法意义。而且一般而言,孤立语缺乏数和格的变化。例如马字,一匹马是马、一群马也是马;而我字,做主语是我、做宾语是我、做定语还是我。 2、屈折语,代表:印欧语系诸语言 屈折语是以词形变化作为表示语法关系的主要手段的语言,特点是有丰富的词形变化来表示词与词之间的关系。这里的“屈折”是指词内部的语音形式的变化,也叫做内部曲折。 3、黏着语,代表:土耳其语、日语、维吾尔语 黏着语是一种语言的语法类型,通过在词根的前中后粘贴不同的词尾来实现语法功能。语法意义主要由加在词根的词缀来表示的,词缀分为前缀、中缀、后缀,常见的有前缀、后缀。 4、复综语(编插语、多式综合语),代表:美洲印第安语 复综语的特点是把主语、宾语和其它语法项结合到动词词干上,以构成一个单独的词,但表达一个句子的意思。其特征是:句子是基本的语言单位,没有独立存在的造句基本单位——词。词和句子合二为一,一个词的构成部分同时也是另一个词的组成部分,许多成分互相编插组合在一起连缀成句子。 语言学上这两种分类方法,是从不同的角度和特征对世界语言进行分类,各有特点,不能说孰优孰劣,都对语言的研究起着重要的作用。2023-07-30 04:43:281
化学专业翻译
更好被定义和健壮在卤素接合的样式他们本质上地倾向于形成的使用模块,允许这分子间的互作用的特征的一项更加深刻和更加微妙的研究。 多卤化的碳衍生物拥有这些定义和强壮要求和已经使用了与各种各样的给电子体。 例如, triiodoand tribromomethane以及他们的tetrasubstituted类似物从六十年代初使用了,当,最近,特护被支付了对diiodobenzene [10]时和iodoacetylenene [11种]衍生物。 一定对碳框架,这些化合物不同的卤素原子不直接地互动自己从电子观点,并且因而工作作为独立接受器站点,介入他们中的一个在导致结实的卤素接合在分子的其他卤素原子的约束能力不改变。2023-07-30 04:43:502
甘氨酸是甚么?
更新1: 对身体好吗? 甘氨酸 [编辑首段] *** ,自由的百科全书 跳转到: 导航 搜索 帮助编辑甘氨酸 IUPAC中文命名 氨基乙酸 Glycine 三字母简写 Gly 单字母简写 G 分子式 C2H5NO2 摩尔质量 75.07 g/mol 熔点 535 K (分解) 密度 1.067×103 kg/m3 pKa1 2.34 (-COOH) pKa2 9.60 (-NH3+) pI 5.97 蛋白质中出现几率 7.2% Δc HmO -981.1 kJ/mol Δf HmO -528.6 kJ/mol CAS号 56-40-6 SMILES NCC(=O)O 若非注明,所有数据都依从国际单位制,以及来自标准状况的条件。 甘氨酸(缩写为G)是20个胺基酸中最简单的一个,是一个非极性的胺基酸。甘氨酸的侧键是一个氢原子。由于其α碳还有一个氢原子,甘氨酸不是旋光异构的。 由于甘氨酸的侧键非常小,它可以占据其它胺基酸无法占据的空间,比如作为胶原螺旋内的胺基酸。 在一些蛋白质中(比如细胞色素、肌红蛋白和血红蛋白)它随着进化的演变变化相当小,因为假如一个比较大的胺基酸取代它的话整个蛋白质的结构就会变化。 大多数蛋白质只含少量甘氨酸,胶原蛋白是一个重要的例外,它含三分之一的甘氨酸。 目录 [隐藏] 1 特性 2 合成 3 生理作用 4 太空中 [编辑] 特性 甘氨酸的水溶性非常好,20℃时每立升水中可以溶解225克甘氨酸。 [编辑] 合成 甲醛、氰化氢和水可以合成甘氨酸: [编辑] 生理作用 在中枢神经系统,尤其是在脊椎里,甘氨酸是一个神经递质的抑制剂。假如甘氨酸接受器被激活,氯离子通过离子接受器进入神经细胞导致抑制性突触后电位。马钱子碱是这些离子接受器的拮抗物。在鼠体内其LD50指标为0.96毫克/千克体重,死因是超兴奋性。在中枢神经系统中甘氨酸与谷氨酸同是激动剂。 生物可以在细胞内自己合成甘氨酸。 [编辑] 太空中 1994年伊利诺大学的一个天文学家组称他们在太空中发现了甘氨酸分子。但后来的分析发现这个发现无法证实。2003年国立台湾师范大学的管一政与Steve Charnley使用无线电望远镜在三个星际物质中发现了27条甘氨酸的光谱。电脑模拟和实验室里的试验证明含简单有机分子的冰可能可以在紫外线的照射下形成甘氨酸。 2004年10月的详细研究证明在所提到的三个星际物质中无法找到甘氨酸的迹象。 假如的确能够在太空中找到甘氨酸的话并不说明地球以外的确有生命,但它说明在星际物质中可以形成胺基酸,它也可以作为有生源说的一个间接支持。 检 u2022 论 u2022 编 u2022 历主要生物化学物质种类 肽 | 胺基酸 | 核酸 | 糖类 | 脂类 | 萜类 | 类胡萝卜素 | 四吡咯 | 辅因子 | 类固醇 | 类黄酮 | 生物碱 | 聚酮 | 配糖类 Analogues of nucleic acids: 常见胺基酸 Analogues of nucleic acids: 脂肪族: 缬氨酸 Val | 异亮氨酸 Ile | 亮氨酸 Leu | 蛋氨酸 Met | 丙氨酸 Ala | 脯氨酸 Pro | 甘氨酸 Gly 芳香族: 苯丙氨酸 Phe | 酪氨酸 Tyr | 色氨酸 Trp | 组氨酸 His | 吡咯赖氨酸 Pyl 极性不带电: 天冬酰胺 Asn | 谷氨酰胺 Gln | 丝氨酸 Ser | 苏氨酸 Thr 带正电(pKa): 赖氨酸 Lys (≈10.8) | 精氨酸 Arg (≈12.5) | 组氨酸 His (≈6.1) 带负电(pKa): 天冬氨酸 Asp (≈3.9) | 谷氨酸 Glu (≈4.1) | 半胱氨酸 Cys (≈8.3) | 酪氨酸 Tyr (≈10.1) | 硒半胱氨酸 Sec 必需胺基酸 | 蛋白质 | 肽 | 遗传密码 一级结构→ 取自"zh. *** /w/index?title=%E7%94%98%E6%B0%A8%E9%85%B8&variant=zh-" 3个分类: 已有表格的化学物质 | 胺基酸 | 神经递质 甘氨酸(缩写为G)是20个胺基酸中最简单的一个,是一个非极性的胺基酸。甘氨酸的侧键是一个氢原子。由于其α碳还有一个氢原子,甘氨酸不是旋光异构的。 由于甘氨酸的侧键非常小,它可以占据其它胺基酸无法占据的空间,比如作为胶原螺旋内的胺基酸。 在一些蛋白质中(比如细胞色素、肌红蛋白和血红蛋白)它随着进化的演变变化相当小,因为假如一个比较大的胺基酸取代它的话整个蛋白质的结构就会变化。 大多数蛋白质只含少量甘氨酸,胶原蛋白是一个重要的例外,它含三分之一的甘氨酸。 甘氨酸的水溶性非常好,20℃时每立升水中可以溶解225克甘氨酸。 甲醛、氰化氢和水可以合成甘氨酸: 图片参考:upload.wikimedia/math/a/5/4/a546867f29b85b38b8cc0200ee0b3357 在中枢神经系统,尤其是在脊椎里,甘氨酸是一个神经递质的抑制剂。假如甘氨酸接受器被激活,氯离子通过离子接受器进入神经细胞导致抑制性突触后电位。马钱子碱是这些离子接受器的拮抗物。在鼠体内其LD50指标为0.96毫克/千克体重,死因是超兴奋性。在中枢神经系统中甘氨酸与谷氨酸同是激动剂。 生物可以在细胞内自己合成甘氨酸。 1994年伊利诺大学的一个天文学家组称他们在太空中发现了甘氨酸分子。但后来的分析发现这个发现无法证实。2003年国立台湾师范大学的管一政与Steve Charnley使用无线电望远镜在三个星际物质中发现了27条甘氨酸的光谱。电脑模拟和实验室里的试验证明含简单有机分子的冰可能可以在紫外线的照射下形成甘氨酸。 2004年10月的详细研究证明在所提到的三个星际物质中无法找到甘氨酸的迹象。 假如的确能够在太空中找到甘氨酸的话并不说明地球以外的确有生命,但它说明在星际物质中可以形成胺基酸,它也可以作为有生源说的一个间接支持。2023-07-30 04:43:591
一篇2500词左右的生化英文论文求翻译,英语不好,拜托各位高手了(不要用软件翻)
马可波罗样激酶1(PLK 1)是一个重要的目标,抗癌疗法由于其所需的功能在细胞分裂,以及提高灵敏度癌细胞失活。几plk1-targeted药物已经出现,包括bi-2536和zk-thiazolidinone(鲎)。这些抑制剂及逮捕细胞有丝分裂和表型符合下调Plk 1的其他means.bi-2536和药理优化模拟(bi-6727)已表明希望的活动迹象的初步临床试验。化学基因系统抑制能力也得到了发展。在这个系统中,两个拷贝的PLK 1基因被删除的永生化人视网膜色素上皮细胞通过定位和cre-lox-mediated重组。在酶Cre介导的切除,PLK 1–/–克隆无法除非他们补充表达Plk 1反,要么野生型(plk1wt)或复合突变(l130g c67v;此后plk1as)。通过扩大激酶的活性位点,后者突变允许Plk 1接受笨重的嘌呤类似物如三磷酸腺苷竞争抑制剂。我们在这里报告,这些突变也有意外影响脱敏Plk 1临床有用的抑制剂如bi-2536和塔尔。(结构使用的所有化学品都显示在补充图1。)检查中抗增殖活性的bi-2536,我们发现,这种化合物强烈迟钝增长plk1wt细胞,但很少或根本没有影响plk1as细胞(图1,2)。要确定是否改变抑制剂效力是独一无二的bi-2536,我们进行类似的growth-challenge实验环境,结构不同的Plk 1抑制剂。再次,我们观察到显着差异plk1as细胞和基因plk1wt同行(数字集成电路,开发)。理解的深度和广度抑制剂抵抗,我们询问体内多种读数及活动。PLK 1需要在整个有丝分裂,良好的作用,中心体成熟,双极纺锤体组装,稳定的动粒微管的附件,并开始胞质。所有这些程序证明是定性和定量抗两种plk1-targeted抑制剂。例如,plk1as细胞继续招募γ-微管蛋白的中心体(一种基本表现中心体成熟)和形式双极纱锭中存在的bi-2536(图2)和塔尔(图乙)。同样,hyper-phosphorylation BubR 1能力(一个关键因素,稳定的动粒微管附件)是不受减损,体现在如BubR 1多肽的持续流动转移电泳(图2)。符合这一广泛的缺陷,这两种化合物造成plk1wt(但不plk1as细胞)逮捕的有丝分裂,看他们的圆形外观相差显微镜(如图4所示)。2023-07-30 04:44:312
求解一段Matlab代码,请详细说一下什么意思,尤其是数据调取方面
能把cfg文件发过来吗?调试用,我正在写注释cfg_len = length(cfg{1,1});%求cfg{1,1}的长度并赋给cfg_lencfg_string = cell(size(cfg));%生成一个空元胞数组,大小为size(cfg),命名为cfg_stringfor i = 1:cfg_len %开始for循环 temp_string = char(cfg{1,1}{i});%把元胞cfg{1,1}{i}内容变为字符 cfg_string{i} = strread(temp_string, "%s", "delimiter", ",")";%读出字符end% Comtrade File IdentifierTitle = char(cfg_string{1,1}(1));%读出文件标识% Comtrade Versionif length(cfg_string{1,1}) < 3; %#ok<ISMT> %确定文件版本年代,若是2位数,就改为1999 Version = "1999";%else Version = char(cfg_string{1,1}(3));%否则就不变end% Channel information: total, analogues and digitalsNo_Ch = strread(char(cfg_string{1,2}(1)));%变换并读出元胞1,2,3的内容,分别是总数,Ana_Ch = strread(char(cfg_string{1,2}(2)));%模拟Dig_Ch = strread(char(cfg_string{1,2}(3)));%数字% Nominal frequency frequency = strread(char(cfg_string{1,3+No_Ch}(1)));%读出并存为频率rates = strread(char(cfg_string{1,4+No_Ch}(1)));%读出并存为速度ratesNo_Ch =No_Ch+rates-1;%总号数更新% Sampling ratesamp_rate = strread(char(cfg_string{1,5+No_Ch}(1)));%读出采样率% Data length, i.e. no of samplesdat_len = strread(char(cfg_string{1,5+No_Ch}(2))); %读出数据长度% Record startedstart_date = char(cfg_string{1,6+No_Ch}(1));%开始日期start_time = char(cfg_string{1,6+No_Ch}(2));%开始时间% Record endedend_date = char(cfg_string{1,7+No_Ch}(1));%结束日期end_time = char(cfg_string{1,7+No_Ch}(2));%结束时间code=char(cfg_string{1,8+No_Ch}(1));%读出代码assignin("base","code", code);%把code的值赋给工作空间的变量名code2023-07-30 04:44:391
Protein 翻译成中文什么意思?》
protein:[pru0259uti:n]a.蛋白质的n.蛋白质[形容词proteinaceous]例句与用法1.Youshouldeatmorehigh-proteindiet.你应该多吃些高蛋白食物。2.Pulsesareagoodsourceofproteinforvegetarians.对於素食者来说,豆类食物是蛋白质的理想来源.3.Trytobalanceyourdietbyeatingmorefruitandlessprotein.多吃些水果,少摄入些蛋白质,使饮食均衡合理.4.Avegetariangetsproteinnotfrommeatbutfromitsanalogues.素食者所摄取的蛋白质不是来自肉类而是来自近似肉类的食物.5.Youneedmoreproteintobuildyouup.你需要增加蛋白质以增强体质.2023-07-30 04:44:461
游效曾的著作论文
1. 《配合物结构和性质》,科学出版社,北京,1992。2. 《分子材料--光电功能化合物》,上海科学技术出版社,上海,2001。3. Youngkyu,Do,Xiao-Zeng You,K.Isobe,“Organometallic Oxide Cluters (RhCp)2Mo3O9(Ome)4 and (RhCp*Mo8O22)”,J. Am. Chem. Soc.,11,106 (1991)4 . You Xiao-Zeng,Tero-Kubota,Fang Wai-hai,“Time Resolved EPR Spectra of Photo-induced Intramolecular Proton Transfer in Schiff-base”,J. Chem. Soc,Chem,Commun.,2391 (1994)5.Shen Zhen,Zuo Jing-lin,You Xiao-zeng,“Ferromagnetic Ordering in 2D Copper Complex,Angew. Chem. Inter. Ed.,Engl.,39,3633,(2000)6. Zhang Yong,Gao Zi-jian,You Xiao-Zeng,“Hydrolysis Theory for Cisplatin and its Analogues”,J. Am. Chem. Soc.,121,9378,(2001)7. Xiiong Ren-gen,You Xiao-zeng,Abrahams B.F..,“Enantioseperation of Racemic Organic Molecule by a Zeolite Analogue”,Angew. Chem. Inter. Ed.,Engl.,47,4422,(2001)8. Yun-Qi Tian,Chen-Xin Cai,Xiao-Zeng,You.”A Mettal-Organic Open-franmework with Zeolite-like Topology”,Angew. Chem. Inter. Ed.,Engl.,41,No.8.3800,(2002)9. Shi Wang,Jing-Lin Zuo,Song Gao,You Song,Hong-Cai Zhou,Yuan-Zhu Zhang and Xiao-Zeng You,“The Observation of Superparamagnetic Behavior in Molecular Nanowires”,J. Am. Chem. Soc.,2004,126(29),8900,(2004).10. Shi Wang,Jing-Lin Zuo,Hong-Cai Zhou,Hye Jin Choi,Yanxiong Ke,Jeffrey R. Long,and Xiao-Zeng You,“[(Tp)8(H2O)6CuII6FeIII8(CN)24]4+: A Cyano-Bridged Face-Centered Cubic Cluster with Single-Molecule-Magnet Behavior”,Angew. Chem. Int. Ed.,43,5940 (2004)..11. Song,You; Zhang,Peng; Ren,Xiao-Ming; Shen,Xiao-Fei; Li,Yi-Zhi; You,Xiao-Zeng. “Octacyanometallate-Based Single-Molecule Magnets: CoII9MV6 (M = W,Mo)”. . J. Am. Chem. Soc. 127(11),3708 (2005)2023-07-30 04:44:531
麻烦翻译成日文的罗马拼音。拜托~~~多谢啦~~~~~
你需要什么?日语都不知道,却要罗马字母???2023-07-30 04:45:572
如何利用论文下面的注释去找原文?
最快捷的方法是用查重工具,网上有很多查重工具,这样就可以很方便找到,那些是引用的了。2023-07-30 04:46:083
于沛的科研情况
研究方向: 对中药有效成份分子结构进行系统的化学修饰;药物合成与质量研究;药物合成工艺优化等。 工作成效: 发表学术论文40余篇,申请发明专利(包括PCT)近30项,曾主持过国家新药创制重大专项、国家科技计划、省、市重大专项等科技项目20项。指导本科毕业生多人获优秀毕业论文,参与指导的第七届“挑战杯”中国大学生创业计划竟赛,荣获全国“金奖”。被暨南大学评为2010年度科研先进工作者,被国际学院评为2012年度最佳全英授课教师。 教学工作 主讲本科专业必修课:全英课程 Medicinal Chemistry 和Experimental MedicinalChemistry 参与本科专业选修课:药学英语 主讲研究生课程:实验室安全知识,药品生产质量管理,化学制药工艺学 在研项目 1、国家“重大新药创制”科技重大专项 2009ZX09102-010 具有降糖和保护胰岛双重功能的糖尿病I类新药AL-1的临床前研究(主持) 2、国家“重大新药创制”科技重大专项2009ZX091030-031 抗脑中风侯选一类新药TBN的开发研究(参加) 3、广州对外科技合作专项,2011-2013年,项目编号11S52070024 治疗帕金森病新型药物的研究开发(主持) 4、广东省教育厅科研项目,2012-2013年,新型抗心肌缺血药ADTM的研究开发(主持) 5、第十三批教学改革研究项目,2012年,药学应用型人才培养毕业设计模式的探索与实践(主持) 代表论文: 1. Zhongli Wang, Pei Yu,* et.al. Design, synthesis and antibacterial activity of novel andrographolide derivatives. Bioorganic & Medicinal Chemistry.2010,18,4269. 2. Hongli Sun, Lipeng Xu, Pei Yu et.al.Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg & Med. Chem. Lett. 2010,20(13),3844. 3. Xiaoyu Lu, Jie Jiang, Xiaojian Jiang, Sainan Wan, Wenjing Yang, Pei Yu. et.al Synthesis and Biological Evaluations of Novel Apocynin Analogues. Eur. J. Med. Chem. 2011, 46(7), 2691. 4. Zai-Jun Zhang, Sha Li, Jie Jiang, Pei Yu, Jing Liang, and Yu-Qiang Wang. Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models Chinese Medicine. 2010, 5, 36. 5. Zhang Gaoxiao, Cui Qingbin, Yu Pei, Wang Yuqiang*, Synthesis and preliminary evaluation of anti-HIV agent AZT prodrug. Acta Pharmaceutica Sinica, 2011. 46(8), 1015. 6. Hui YAO, Sha LI, Pei YU, Xiaodan TANG, Yuqiang WANG Characteristics of Andrographolide and its Analogue AL-1 with GSH . Molecules 2012, 17, 728-739 7. Zeqing Li, Zhibin Liang, Yuqiang Wang , Pei Yu* Microwave-assisted, Ir catalyzed aromatic C-H borylation. Research on Chemical Intermediates 2012. 8. Sun, Y.; Zhang, G.; Zhang, Z.; Yu, P.; Zhong, H.; Du, J.; Wang, Y. Novel multi-functional nitrones for treatment of ischemic stroke,Bioorg. Med. Chem. 2012, 20, 3939–3945. 9. Yonghong Chen, Mingjuan Zhang, Qingbin Cui, Luchen Shan, Pei Yu, Gaoxiao Zhang, Dingyuan Wang, Zengchao Zhao, Qian Xu, Benhong Xu, Yuqiang Wang. Synthesis and Cardioprotective Effects of Novel Danshensu Analogues. Eur J Med Chem. 2012. (In press) 10. Pei Yu, Longfei Xia, Jing Zhao, Gaoxiao Zhang, Zaijun Zhang, Wei Li, Junlan Ren, Qian Cheng,Yuqiang Wang* Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs. Biol.Pharm. Bull. 2012, 35(8), 1-5. 11. Yewei Sun, Pei Yu, et.al. Therapeutic Effects of Tetramethyl- pyrazine Nitrone in Rat Ischemic Stroke Models. Journal of Neuroscience Research2012, 90, 1662–1669. 12. GuoZhen Cui, Luchen Shan, MingWai Hung, Siwan Lei, InLeng Choi, ZaiJun Zhang,Pei Yu, PuiMan Hoi, Yuqiang Wang, Simon MingYuen Lee. A novel Danshensu derivative confers cardioprotection via the PI3K/Akt and Nrf2 pathways. Int J Cardiol. 2012.2023-07-30 04:46:151
100句英语短语涵盖所有词汇
1、 On this area of the sea, the pandas like to drink tea with peas in soda.在海里的这个地区,熊猫们喜欢就着苏打碗豆喝茶。 2、 And the Oceanian militias like to go to cafeteria via the peninsula with a formula of dramas.而大洋州的民兵则喜欢经过半岛,带着编剧本的公式上餐厅去。 3、 There are extra operas as well as bananas in a cinema nearby. The zebra in this era get attracted by the antennas outside.附件的电*里有额外的歌剧和香蕉,这一时代的斑马们被外面的天线所吸引。 4、 The crab in lab wants to stab a lamb with his rib, whose limbs were like bulbs.实验室里的蟹想用它的肋骨去戳四肢象灯炮的小羊。 But the lamb uses her thumb to bomb the crab"s dumb comb and sends it to the tomb.但小羊用拇指投了个炸弹,炸中了蟹的哑梳子,把它送进了坟墓。 5、 Meanwhile, the mob outside robs her and the lamb sobs in the cafeteria.这时,门外的乌合之众抢劫了小羊,它只得在餐厅里抽泣。 6、 So she absorbs herself in rubbing tubs in a club in the suburb, only to avoid being disturbed by the mob.于是它专心地躲在郊外的一个俱乐部里擦拭浴盆,逃避乌合之众们的打扰。 The specifically pacific gives a magic mechanic to catholic republic publically with terrific photography and academic logics. 特别爱好和平的商人们公开地给了宽容的共和国一个魔力的技工,连同极妙的照片及学术性的逻辑学。 7、 And a dynamic clinic shows the traffickers the formula of cosmic economics organically on a panicky picnic. 而一间充满活力的诊所在一个恐慌的野餐会上给商人们有机地展示了宇宙经济学的公式。 8、 So the heroic lamb flies from the atmosphere Antarctic at a supersonic speed, who then corrects them with a photoelectric lactic synthetically.故此,英勇的小羊从南极的大气层以超声速飞来,并用一个综合的光电策略观纠正了他们。 9、 Even the static critic feels her solution energetic and sympathetic, just like piece of magnetic music with arithmetic.甚至连静态批评家都觉得这一解决方式富有活力,及同情心,就如一曲有磁性有计算意味的音乐。 10、 The patriotic and enthusiastic has a lot of elastic plastics domestically and fantastically, too.爱国而又热情的评论家还有许多弹性的塑料品在家中,充满了想象。 11、 The odd lad"s pad makes his thread mad.这个奇怪的小伙子的填料让线变疯了。 12、 His succeeding advanced deeds exceed the critic"s proceeding feed of bleeding need, too.他连续不断的先进行为也超过了评论家正在研制的以流血的贫穷制作的饲料。 13、 The greedy reed speeds breeding its seeds in the shed.贪婪的芦苇加快在小屋培育种子。 14、 A crowd of wicked naked girls get accustomed to so-called being learned, as well as the hatred of being sacred.一群邪恶的*女习惯了所谓的有学问,和对神圣的厌恶。 15、 A sophisticated house was situated undoubtedly on an unlimited road, owned by a complicated wedding beloved maid who was afraid of air-raid.毫无疑问,一座复杂而先进的房子,座落在一条无限制的马路上,由一个复杂受到爱戴的结婚少女所拥有,她害怕空袭。 16、 The stupid invalid has rigidly forbidden the kid"s bidding for the producing of solid acid in a humid, but splendid field with a rapid lid. 愚蠢的病人严厉地用一个快盖子禁止了小孩对在一个潮湿而华丽的地带生产固体酸的投标。 17、 But the wild child boldly gets rid of him with a fluid shield and has yielded a building without welds.但这狂野的小孩勇敢地以一种流体质除去了他,成功地生产了一座无焊点的建筑。 18、 After upholding to scold the folded wife, a second-hand husband moulds the threshold in shorthand on the highland.在赞成责骂被折叠的妻子之后,二手丈夫在高地以速记法铸成了一个门槛。 19、 Demands of beforehand commands expand so rapidly that several grand bands of them have already withstood their descenderce of both prices and manufactures.对预警命令的需求扩张得如此之快,以致于有几个大品牌已能经受价格及产量的下跌。 20、 My legendary friend has recommended me to the lent to blend our weekends with suspension of less expense. 我传说中的朋友已推荐我被借去把我们的周末与减少花费的暂停相泯合。 ....... 61、 We have a brittle bottle in which a startle castle was settled. 62、 A mule of molecule has been scheduled. 一头分子做骡子被安排好了。 63、 The Queen is a famed supremacy by the fame of themes of her husband"s scheme. 女王是由她丈夫设定的计划主题框架 64、 Handsome men are wholesome, though tiresome. 英俊的男人有益健康,虽也令人疲倦。 65、 The mining of pining nine has led to the lack of genuine magazine.对松类藤的开采导致了真弹药的缺乏。 66、 The throne of limestone was hoed by the farmers on canoe.石灰王座被独木船上的农民锄坏了。 67、 Some ripe grapes have been scraped into stripes. 有些成熟的葡萄被擦成条状。 68、 Our warfare welfare was declared to be prepared in the flare of people"s glare.我们的战争福利在民众的怒视的目光中被宣布已准备就绪。 69、 Hegemony adheres not only on both hemispheres, but also upwards to our commonly shared atmosphere. 霸权主义不上存在于东西半球,还存在于大气层。 70、 The entire empire was highly inspired by the desire of grasping the wire bire. 整个帝国被攫取电线胎的欲望所鼓动起来。 71、 Never ignore your sore caused by the ore. 绝不要小视由矿石引起的疼痛。 72、 Your obscure procedure has secured the immeasurable treasure and ensures the leisure enclosure of any possible exposure. 你们模糊不清的程序将保证会得到无数的珍宝,并将轻松地保证不含有任何曝光的可能。 73、 A mature creature features with better architecture and venture.成熟的人以比前更好的建筑设计及冒险特征。 74、 This gesture is actually a torture for the captured man with such high moisture. 在如此潮气之下,这种装扮实际是对这个被捕者的折磨。 75、 Paradise has concise promise and precise merchandise such as tortoise and compromise of despised praise. 天堂有简明的许诺,精确的商品,如龟及对被蔑视赞美的妥协。 76、 A disguise comprises an enterprise and good supervision. 伪装由计划和良好的监督组成。 77、 Condensing this dense material will take immerse expense and intense work. 压缩这一密度大的物质将花费巨大的开支及紧张的工作。 78、 King"s purpose of imposing a new tax has been soon exposed and even the decomposed dead will be supposed to oppose his luxurious proposal. 国王加征新税的目的很快被告之于众,甚至连土里烂掉的死人也应该起来反对他靡华的求婚。 79、 A glimpse of the eclipse is enough to disperse your coarse verses poems from your cursed horseback. 看一眼日食就足以驱散你在你该诅咒的马背上得来的粗糙的诗句。 80、 Their pause of applause shall have no excuse. 他们的暂停鼓掌将不会有任何借口。 81、 A mouse in our warehouse has been aroused by the greenhouse effect and it can amuse everyone. 我家库房里有只老鼠被温室效应唤醒,它能取悦于人。 82、 Lao Sha"s dedicated debate indicates that his delicate certificate of a good speaker has no complicated duplicate and can hardly be located by his advocates. 83、 A number of candidates have consolidated their accommodation with investigation and appreciation. 一些候选人已用调查及感激巩固了他们的住处。 84、 Appropriate intermediate can radiate without much deviation since its initiation. 适当的媒介可以在辐射开始时就产生较小偏差。 85、 You can regulate the ventilation of the insulators by calculating the circulation of manipulated chocolate. 你可以通过计算机受控巧克力的循环来调节绝缘体的通风。 86、 Our classmates in the senate have designated their fascinating subordinates to coordinate the origination and elimination of the dominant anticipation. 我们参议院的同学已指派他们迷人的下属协调主导期望的产生及消灭。 87、 Fortunately, the main illumination has become moderate after the exaggerated overuse of the rated generutor and the cars are accelerating with less tolerance and deliberate vibration. 很幸运地,主照明系统在满受骂名的发电机被夸大的超负运转下得以运转有度,车子也更不耐心地加速着,还故意地振动着。 88、 With the collaboration of the elaborate evaporating system, the demonstration can perforate the decorated confidence of the concentrated audience without much illustration or frustration accurately. 在精细的蒸发系统的帮助下,演示能不用任何插图或挫折就穿过全神贯注的观众们矫饰的自信。 89、 The evaluation of an athlete will fluctuate or elevate if he has been better cultivated or hesitate to imitate a greater graduate concretely. 对运动员的估价将会波动或上升,如果他受到了更好的教化或者在模仿。 90、 Lao Yu"s citation has ignited the infinite spite of his favorite"s appetite. 老俞的引用点燃了他宠物胃口的无限怨恨。 91、 A acute persecutor has been executed with salutes of flutes, and refutation of an absolute mute. 一个为害极大的迫害者在笛子的致敬和一个全哑之人的驳斥声中被处决了。 92、 His institute has constituted a substitute for disputers with minute route of rescuers. 他的学院已组建了带有一小路拯救队的争论者的替代者。 93、 This vague dialog of fatigue has been catalogued with its analogues.这一种关于疲乏的对话已与其类似的东西一起被编入了目录。 94、 The pursuit of the police"s unique technique has made the avenue a new clue of the tissue case. 警方对他们独特技术的追击使得大道成为了织物这案子的新线索。 95、 Our brave weavers have turned their pavement grave of their slave-owners. 我们英勇的织工已把人行道变成了他们主人的坟墓。 96、 The grieving divers have conceived the deceit without any received perception. 悲哀的潜水员们已构思出不会被察觉的骗局。 97、 The thriving races are striving for a decisive derivation of their deprived rights. 发展中的种族们正奋斗着,以期能获得对他们失去权利决定性的来源。 98、 Successive massive explosive has been approved to be too aggressive and excessive for any progressive impressions. 连续不断的大块爆药被证明对于进步印象而言过于具侵略性以及过多了。 99、 Nothing can be comparative alternative to regenerative initiative or negative representatives. 没什么东西可以作为新生的进取心或是消极代表的可相比拟的替代者。 100、 The conservative detectives have made themselves both qualitatively and quantitatively destructive and sensitive for positive perspective respectively. 这群保密的侦探把他们自己变成不论是在量上还是在质上都既敏感又具破坏力,这是为了他们各自的前景考虑。2023-07-30 04:46:281
「神奇的小分子活性肽」第二章·第三节活性肽的分泌周期
在不同的年龄时期,各种生物活性肽的分泌量也有很大差别,按分泌量划分,人的一生一般可分为以下4个时期: 1)分泌旺盛期(25岁以前的青年期) 这个时期内分泌系统功能旺盛,各种生物活性肽分泌量均衡,人体免疫功能强,人体一般不易出现疾病。25岁以后分泌量将以每10年下降15%的速度逐年减少。 2)分泌不足期(30~50岁壮年和中年期) 30岁左右,人体各器官组织开始老化萎缩,功能衰退,各种生物活性肽的分泌量只有巅峰期的85%。人到了45岁左右,无论男女从外观(如皮肤急剧松弛、老化)到机体生理(性腺功能减退)都会出现急剧的衰退现象,人体神经系统、免疫系统的功能发生一系列的改变,出现各种相关的亚健康状态和轻微疾病症状。 3)分泌匮乏期(50岁以上中年和老年期) 到60岁时,活性肽的分泌量只有巅峰期的1/5左右,到80岁时,只余下1/10不到了。这一时期如果活性肽严重不足和严重失衡,可能出现非常突出的衰老症状,或会引起各种相关疾病发生。 4)分泌终止期 这一时期由于细胞功能衰退,器官功能衰竭和丧失,不再分泌活性肽,从而导致生命走向终结。随着人体的自然衰老,人体分泌活性肽数量会逐渐减少。而现代生活节奏快、生存竞争激烈、情绪压力大、环境污染,不健康饮食结构等因素造成人体普遍处于“亚健康”状态,各功能器官负荷过重,生理机能下降。外源性小分子肽,不但有极强的营养价值,还具有调节人体的代谢和生理功能,对维持正常的生命活动非常重要。因此,对任何人群来说,补充外源性小分子肽都是非常有益的。 参考文献 [1] 李勇.肽临床营养学[M].北京:北京大学医学出版社,2012. [2] 冯秀燕,计成.寡肽在蛋白质营养中的作用[j].动物营养学报,2001,13(3):8-13. [3] Agar WT,Hird F J,Sidhu G S. The active absoption of amino-acids by the intestine[J].Physiol.,1953,121(2):255一263. [4] Neway H,Smith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J].Physiol.,1996,152:367一380. [5] Daniel H. Molecular and Integrative PhysioI0gy of Intestinal Peptide Transport[J].Annual Rev. Physiol.,2004,66:361一384. [6] zaloga G P . Physiologic effects of peptides based enternal formulae[J].Nutrition in cIinical practice,1990,5:231—237. [7] Hara H,Funabili M,Iwata,et al . Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr.,1984,114:1122—1129. [8] Leonard J V,Marrs T C,Addison J M,et al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J].Pediatr Res.,1976,10(4):246—249 [9] 李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014,26(1):17一25. [10] 王春艳,田金强,王强.改善心血管健康的食源性生物活性肽构效关系研究进展[J].食品科学,2010,31(13):307一311. [11] 李世敏.食源性活性多肽与降血压研究进展日[J].老年医学保健,2008,14(2):125一127. [12] Dziuba J,Minkiewicz P,Nalecz D,et al. Database of biologically active peptide sequences[J].Nattrunges.,1999,43:190—195.‘ [13] Shin Z,Yu R,Park S A,et al. His-His-Leu ,an angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste,exerts arltihyPertensive activity in vivo[J].J Agric Food chem.,2001,49(6):3004一3009. [14] Hirasawa M , Shijubo N,Uede T,et al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J].Br J Cancer.,1994,70(3):466—473. [15] Florentin l,Chung V,Martinez J,et al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J].Methods Find Exp Clin Pharmacol.,1986,8(2):73—80. [16] Tsuchita H,Suzuki T,Kuwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J].Br J Nutr.,2001,85(1):5一10. [17] 张昊,任发政.天然抗氧化肽的研究进展[J].食品科学,2008,29(4):443一447. [18] 张莉莉,严群芳,王恬.大豆生物活性肽的分离及其抗氧化活性研究[J].食品科学,2007,28(5):208一211. [19] 荣建华,李小定,谢笔钧.大豆肽体外抗氧化效果的研究[J].食品科学,2002,23(11):118一120. [20] 崔剑,李兆陇,洪啸莺吟.自由基生物抗氧化与疾病[J].清华大学学报自然科学版,2000,40(6):9一2. [21] 陆融,王卓.小分子多肽抗肿瘤作用的研究进展[J].天津医科大学学报,2005,11(3):499一502. [22] Chène P,Fuchs J,Bohn J,et al. A small synthetic peptide , which inhibits the p53-hdm2 interaction,stimulates the p53 pathway in tumour cell lines[J].J Mol Biol.,2000,299(1):245一253. [23] Issaeva N,Friedler A,Bozko P,et al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J].Proc Natl Acad Sci USA.,2003,100(23):13303一13307. [24] 朱维铭.临床营养角色的转变:从营养支持到解怡疗[J].肠外与肠内营养,2009,16(1):1—3l. [25] 裴新荣,杨奋悦,张召锋,等.海洋胶原肽抗皮肤老化作用的实验研究[J].中华预防医学杂志,2008,42(4):235—238. [26] 梁锐,张召锋,赵明,等.海洋胶原肽对剖宫产大鼠伤口愈合促进作用[J].中国公共卫生,2010,26(9):1144一1145. [27] 王竹青,李八方.生物活性肽及其研究进展[J].中国海洋药物杂志,2010,29(2):60一68. [28] 何平均.抗肿瘤寡肽类药物研究进展[J].中国医药生物技术.2009,4(4):288一290. [29] 孙立春,COY David H.多肽药物研究进展[J].上海医药,2014,35(5):55一60. [30] Fang H,Luo M,Sheng Y,et al. The antihypertensive effect of peptides:a novel altemative to drugs?[J].Peptides,2008,29(6):1062一1071. [31] 聂彩辉,徐寒梅.多肽药物的发展现状[J].药学进展,2014,38(3):1:6一202. [32] 李晓玉.安泰胶囊的免疫增强和保肝作用[J].中国药理学通讯,1999,16(2):28一30.2023-07-30 04:46:471
色氨酸属于芳香族还是杂环族?
色氨酸属于芳香族的2023-07-30 04:46:581
「神奇的小分子活性肽」第二章·第一节人体内几种重要的活性肽
已知自然界生物体中存在着数万种生物活性肽,而我们人体中具有活性的肽就有1000种之多,仅脑中就存在近40种,人们还在不断地发现、分离、纯化新的活性肽物质。 通常,人们依据生物活性肽的作用和分泌部位将其分为下丘脑一垂体月亮石激素、消化道激素、其他激素和活性肽。 1)下丘脑一垂体肽激素 丘脑与垂体紧密相连,组成神经内分泌调节系统。包括促肾上腺皮质激素、促甲状腺素释放激素、促性腺素释放激素、生长激素释放激素(CHRH)、生长激素抑制素(CHIH)、促黑色素细胞抑制激素(MRIH)、促黑色素细胞释放激素(MRH)、催乳素释放激素(PRH)、催乳素抑制激素(PIH)、促皮质素释放激素(LRH)、抗利尿激素(ADH)和催产素等。 2)消化道激素 由胃肠道合成的肽类激素包括促胃泌素(34肽)、肠促胰液素(27肽)、缩胆囊素(8肽)、胃动素(22肽)、血管活性肠肽(28肽)、神经降压肽(13肽)等。现已证明,许多胃肠道肽类激素在大脑和外周神经系统中也有发现,称为脑肠肽。这些肽类物质不断调整机体的反应性,以适应内外环境的变化,保证机体的健康状态。 3)其他激素和活性肽 其他激素和活性肽包括胸腺肽、胰岛素、胰高血糖素、降钙素、血管紧张肽Ⅰ(10肽)、Ⅱ(8肽)、Ⅲ(7肽)、内啡肽、脑啡肽、谷胱甘肽等。 下面介绍人体内几种重要的小分子活性肽。 1)谷胱甘肽 谷胱甘肽(GSH)是一种含γ-酰胺键和巯基的3肽,由谷氨酸、半胱氨酸及甘氨酸组成,存在于几乎身体的每一个细胞中。谷胱甘肽能帮助人体保持正常的免疫系统功能,并具有抗氧化作用和整合解毒作用。 2)促甲状腺素释放激素 促甲状腺素释放激素是由下丘脑合成分泌的一种3肽物质.它能促进腺垂体分泌促甲状腺素,后者促进甲状腺细胞增生、合成并分泌甲状腺激素。 3)胸腺肽 胸腺肽是胸腺组织分泌的具有生理活性的5肽物质。 临床上常用的胸腺肽是从小牛胸腺发现并提纯的有非特异性免疫效应的小分子多肽。 胸腺肽能促进淋巴细胞转化,增强巨噬细胞吞噬活性,可用于治疗多种免疫缺陷病。 4)脑啡肽 脑啡肽是由5个氨基酸残基组成的神经肽。脑啡肽广泛存在于中枢神经系统中,在下丘脑前部、尾状核及苍白球处有较高的活性,在中枢神经系统中起神经递质或神经调节物作用,参与抑制痛觉传导,与体温调节、心血管调节、内分泌激素的释放均有关。 5)加压素 加压素(又称抗利尿激素)是由下丘脑的视上核和室旁核的神经细胞分泌的9肽激素,经下丘脑一垂体束到达神经垂体后叶后释放出来。其主要作用是提高远曲小管和集合管对水的通透性,促进水的吸收,是尿液浓缩和稀释的关键性调节激素。 6)催产素 催产素又称缩宫素,是由下丘脑合成、垂体后叶释放的一种 肽物质。催产素在雌性哺乳动物生产时大量释放,可扩张子宫颈和收缩子宫,促进分娩。催产素还能使人对陌生人产生信赖感,有助于治疗孤独症等病。 7)促性腺激素释放激素 促性腺激素释放激素(GnRH)是下丘脑分泌产生的10肽神经激素,刺激或抑制垂体促性腺激素的分泌,对脊椎动物生殖的调控起重要作用。 6)神经降压肽 神经降压肽(NT)是一种由13个氨基酸组成的内源性多肽,主要存在于下丘脑前部与底部、伏核和隔部,脑干和脊髓中主要在胶质带的小细胞中间神经元和三叉神经运动核等处,可使毛细血管通透性增强、皮肤血管扩张、血压降低、促进胰高血糖素释放,抑制胰岛素释放,刺激胃肠道收缩,抑制胃酸分泌等。 随着人们对生物活性多肽认知的不断深入,近年来科学家们逐渐将目光转向活性肽药物的开发。多肽类药主要用于治疗癌症、代谢类疾病、心血管疾病、内分泌类疾病、血液病,缓解疼痛,调节认知等各个领域。 参考文献 [1] 李勇.肽临床营养学[M].北京:北京大学医学出版社,2012. [2] 冯秀燕,计成.寡肽在蛋白质营养中的作用[j].动物营养学报,2001,13(3):8-13. [3] Agar WT,Hird F J,Sidhu G S. The active absoption of amino-acids by the intestine[J].Physiol.,1953,121(2):255一263. [4] Neway H,Smith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J].Physiol.,1996,152:367一380. [5] Daniel H. Molecular and Integrative PhysioI0gy of Intestinal Peptide Transport[J].Annual Rev. Physiol.,2004,66:361一384. [6] zaloga G P . Physiologic effects of peptides based enternal formulae[J].Nutrition in cIinical practice,1990,5:231—237. [7] Hara H,Funabili M,Iwata,et al . Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr.,1984,114:1122—1129. [8] Leonard J V,Marrs T C,Addison J M,et al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J].Pediatr Res.,1976,10(4):246—249 [9] 李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014,26(1):17一25. [10] 王春艳,田金强,王强.改善心血管健康的食源性生物活性肽构效关系研究进展[J].食品科学,2010,31(13):307一311. [11] 李世敏.食源性活性多肽与降血压研究进展日[J].老年医学保健,2008,14(2):125一127. [12] Dziuba J,Minkiewicz P,Nalecz D,et al. Database of biologically active peptide sequences[J].Nattrunges.,1999,43:190—195.‘ [13] Shin Z,Yu R,Park S A,et al. His-His-Leu ,an angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste,exerts arltihyPertensive activity in vivo[J].J Agric Food chem.,2001,49(6):3004一3009. [14] Hirasawa M , Shijubo N,Uede T,et al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J].Br J Cancer.,1994,70(3):466—473. [15] Florentin l,Chung V,Martinez J,et al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J].Methods Find Exp Clin Pharmacol.,1986,8(2):73—80. [16] Tsuchita H,Suzuki T,Kuwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J].Br J Nutr.,2001,85(1):5一10. [17] 张昊,任发政.天然抗氧化肽的研究进展[J].食品科学,2008,29(4):443一447. [18] 张莉莉,严群芳,王恬.大豆生物活性肽的分离及其抗氧化活性研究[J].食品科学,2007,28(5):208一211. [19] 荣建华,李小定,谢笔钧.大豆肽体外抗氧化效果的研究[J].食品科学,2002,23(11):118一120. [20] 崔剑,李兆陇,洪啸莺吟.自由基生物抗氧化与疾病[J].清华大学学报自然科学版,2000,40(6):9一2. [21] 陆融,王卓.小分子多肽抗肿瘤作用的研究进展[J].天津医科大学学报,2005,11(3):499一502. [22] Chène P,Fuchs J,Bohn J,et al. A small synthetic peptide , which inhibits the p53-hdm2 interaction,stimulates the p53 pathway in tumour cell lines[J].J Mol Biol.,2000,299(1):245一253. [23] Issaeva N,Friedler A,Bozko P,et al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J].Proc Natl Acad Sci USA.,2003,100(23):13303一13307. [24] 朱维铭.临床营养角色的转变:从营养支持到解怡疗[J].肠外与肠内营养,2009,16(1):1—3l. [25] 裴新荣,杨奋悦,张召锋,等.海洋胶原肽抗皮肤老化作用的实验研究[J].中华预防医学杂志,2008,42(4):235—238. [26] 梁锐,张召锋,赵明,等.海洋胶原肽对剖宫产大鼠伤口愈合促进作用[J].中国公共卫生,2010,26(9):1144一1145. [27] 王竹青,李八方.生物活性肽及其研究进展[J].中国海洋药物杂志,2010,29(2):60一68. [28] 何平均.抗肿瘤寡肽类药物研究进展[J].中国医药生物技术.2009,4(4):288一290. [29] 孙立春,COY David H.多肽药物研究进展[J].上海医药,2014,35(5):55一60. [30] Fang H,Luo M,Sheng Y,et al. The antihypertensive effect of peptides:a novel altemative to drugs?[J].Peptides,2008,29(6):1062一1071. [31] 聂彩辉,徐寒梅.多肽药物的发展现状[J].药学进展,2014,38(3):1:6一202. [32] 李晓玉.安泰胶囊的免疫增强和保肝作用[J].中国药理学通讯,1999,16(2):28一30.2023-07-30 04:47:251
列举欧洲巴洛克时期、古典音乐时期典型代表人物及国籍(各个时期至少少三位)有分
巴洛克时期 Analogues of nucleic acids: 早期代表:(意大利)蒙泰威尔第、(德国)许茨 中期代表:(意大利)A.斯卡拉蒂、(英国) 珀塞尔、(法国) 吕利、(德国) 帕赫贝尔 晚期代表:(德国)巴赫、(英国)亨德尔、(意大利)维瓦尔第、(意大利)D·斯卡拉蒂、(德国)泰勒曼、(法国)拉莫 古典时期 Analogues of nucleic acids: 早期代表:(奥地利)海顿、(意大利)萨马丁尼、(德国) C·P·E·巴赫、(德国)格鲁克 中期代表:(奥地利)莫扎特、(德国)克雷门蒂 晚期代表:(德国)贝多芬、(奥地利)舒伯特、(丹麦)库劳、(意大利)帕格尼尼、(奥地利)胡梅尔2023-07-30 04:47:311
「神奇的小分子活性肽」第二章·第二节活性肽的主要生理功能(上)
生物活性肽是人体中最重要的活性物质。它在人的生长发育,新陈代谢、疾病以及衰老,死亡的过程中起着关键作用。下面介绍活性肽的主要生理功能。 1)增强免疫 干扰素、白细胞介素等生物活性肽能够激活和调节机体免疫反应,显著提高人体外周血液淋巴细胞的增殖。动物实验和临床研究证明胸腺5肽对免疫功能低下和自身免疫疾病患者的免疫功能具有重要的调节作用。 另有研究显示,蛋白水解产生的一些小分子肽具有免疫活性作用。它们不仅能增强机体的免疫力,而且能刺激机体淋巴细胞的增殖和增强巨噬细胞的吞噬能力。这些免疫活性肽可与肠黏膜结和淋巴组织相互作用,而且也可以进入血液与外周淋巴细胞发生作用。此外,小分子肽还可以增强肝细胞活力,有效地调整淋巴T细胞亚群的功能,增强体液免疫和细胞免疫功能,从根本上提高人体免疫力,是治疗和预防各种肝病的有效制剂。 李晓玉等研究发现,酶解卵白蛋白小分子肽具有激活免疫系统的作用,可以明显使淋巴细胞数量增加、活性增加,对B细胞的功能(抗体的生成)有很明显的促进作用,对T淋巴细胞的增殖也有很明显的促进作用。 2)抗菌、抗病毒 世界上发现的第一种抗菌肽是天蚕素,是由瑞典科学家Boman等人在1980年用蜡状芽孢杆菌(bacillus cereus)诱导惜古比天蚕(hyalophora cecropia)后产生出的有抗菌活性的多肽物质,定名为天蚕素(cecropins)。随后又在其他生物体内陆续发现了多种抗菌肽,如蛙皮素(magainins)、蜂毒素(melittins)、防御素(defensins)等。目前世界上已知的抗菌肽共有1200多种。由于最初人们发现这类活性多肽对细菌具有广谱高效的杀菌活性,因而命名为抗菌肽。 国内外研究成果表明,抗菌肽不仅有广谱抗细菌能力,对部分细菌、真菌、原虫、病毒及癌细胞等均具有强大的杀伤作用。临床试验也表明,在机体感染病菌或可能导致病菌感染的情况下,抗菌肽能够快速杀灭已侵入的病菌,并且能阻止病菌的继续感染。自从发现抗菌肽以来,人们已对抗菌肽的作用机理进行了大量研究,目前已知其作用机理是抗菌肽作用于细菌细胞膜,可通过增加细胞膜的通透性来杀死微生物。 由于全球抗生素药物的滥用,越来越多的细菌可能发展成为对传统抗生素耐药的菌株。人们迫切地寻找能够代替传统抗生素的药物,从而使得抗菌肽受到广泛的重视。 3)抗氧化,延缓衰老 抗氧化活性肽是最近被广泛研究的一类天然活性肽,它们能够有效清除体内多余的活性氧自由基,保护细胞膜和线粒体的正常结构,防止脂质过氧化,而氧化与人类的自然老化和许多疾病诸如癌症、糖尿病、动脉硬化和老年痴呆等的发生发展有密切关系。 肌肽和谷胱甘肽等抗氧化活性肽研究得最多。肌肽是大量存在于动物肌肉中的一种天然2肽,它可以在体外抑制被铁、血红蛋白、脂质氧化酶和单肽氧催化的脂质氧化作用。 谷胱甘肽(glutathione,GSH)是一种由谷氨酸、半胱氨酸和甘氨酸结合而成的3肽。 谷胱甘肽的生物学功能很多,如 它能保护细胞膜免受自由基氧化损伤; 能保护酶分子中的-SH基,有利于酶活性的发挥,并且能恢复已被破坏的酶分子中-SH基的活性功能,使酶重新恢复活性; 能保护血红蛋白不受过氧化氢氧化、自由基等氧化从而使它持续正常发挥运输氧的能力; 能抑制乙醇侵害肝产生脂肪肝; 能与进入机体的有毒化合物、重金属离子或致癌物质等相结合并促其排出体外,起到中和解毒的作用; 能对由放射线、放射性药物或由于抗肿瘤药物所引起的白细胞减少等症状起到很好的缓解作用; 能减少色素沉着的发生,阻止和推迟老年斑的出现等。 近几年,来源于食物蛋白的抗氧化活性肽,由于具有良好的抗氧化活性,而且安全性高,备受国内外科学工作者的关注。大豆多肽是目前研究比较多的食源性生物活性肽。研究表明,大豆生物活性肽除了具有如抑制血压升高、抗疲劳、增强免疫功能及降低胆固醇等许多生理功能外,还具有良好的抗氧化作用。荣建华等研究发现,大豆分离蛋白经中性蛋白酶酶解,酶解物具有较强的抗氧化活性,在浓度为0.1~250mg/ml范围内对·OH都有明显的清除作用。 参考文献 [1] 李勇.肽临床营养学[M].北京:北京大学医学出版社,2012. [2] 冯秀燕,计成.寡肽在蛋白质营养中的作用[j].动物营养学报,2001,13(3):8-13. [3] Agar WT,Hird F J,Sidhu G S. The active absoption of amino-acids by the intestine[J].Physiol.,1953,121(2):255一263. [4] Neway H,Smith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J].Physiol.,1996,152:367一380. [5] Daniel H. Molecular and Integrative PhysioI0gy of Intestinal Peptide Transport[J].Annual Rev. Physiol.,2004,66:361一384. [6] zaloga G P . Physiologic effects of peptides based enternal formulae[J].Nutrition in cIinical practice,1990,5:231—237. [7] Hara H,Funabili M,Iwata,et al . Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr.,1984,114:1122—1129. [8] Leonard J V,Marrs T C,Addison J M,et al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J].Pediatr Res.,1976,10(4):246—249 [9] 李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014,26(1):17一25. [10] 王春艳,田金强,王强.改善心血管健康的食源性生物活性肽构效关系研究进展[J].食品科学,2010,31(13):307一311. [11] 李世敏.食源性活性多肽与降血压研究进展日[J].老年医学保健,2008,14(2):125一127. [12] Dziuba J,Minkiewicz P,Nalecz D,et al. Database of biologically active peptide sequences[J].Nattrunges.,1999,43:190—195.‘ [13] Shin Z,Yu R,Park S A,et al. His-His-Leu ,an angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste,exerts arltihyPertensive activity in vivo[J].J Agric Food chem.,2001,49(6):3004一3009. [14] Hirasawa M , Shijubo N,Uede T,et al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J].Br J Cancer.,1994,70(3):466—473. [15] Florentin l,Chung V,Martinez J,et al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J].Methods Find Exp Clin Pharmacol.,1986,8(2):73—80. [16] Tsuchita H,Suzuki T,Kuwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J].Br J Nutr.,2001,85(1):5一10. [17] 张昊,任发政.天然抗氧化肽的研究进展[J].食品科学,2008,29(4):443一447. [18] 张莉莉,严群芳,王恬.大豆生物活性肽的分离及其抗氧化活性研究[J].食品科学,2007,28(5):208一211. [19] 荣建华,李小定,谢笔钧.大豆肽体外抗氧化效果的研究[J].食品科学,2002,23(11):118一120. [20] 崔剑,李兆陇,洪啸莺吟.自由基生物抗氧化与疾病[J].清华大学学报自然科学版,2000,40(6):9一2. [21] 陆融,王卓.小分子多肽抗肿瘤作用的研究进展[J].天津医科大学学报,2005,11(3):499一502. [22] Chène P,Fuchs J,Bohn J,et al. A small synthetic peptide , which inhibits the p53-hdm2 interaction,stimulates the p53 pathway in tumour cell lines[J].J Mol Biol.,2000,299(1):245一253. [23] Issaeva N,Friedler A,Bozko P,et al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J].Proc Natl Acad Sci USA.,2003,100(23):13303一13307. [24] 朱维铭.临床营养角色的转变:从营养支持到解怡疗[J].肠外与肠内营养,2009,16(1):1—3l. [25] 裴新荣,杨奋悦,张召锋,等.海洋胶原肽抗皮肤老化作用的实验研究[J].中华预防医学杂志,2008,42(4):235—238. [26] 梁锐,张召锋,赵明,等.海洋胶原肽对剖宫产大鼠伤口愈合促进作用[J].中国公共卫生,2010,26(9):1144一1145. [27] 王竹青,李八方.生物活性肽及其研究进展[J].中国海洋药物杂志,2010,29(2):60一68. [28] 何平均.抗肿瘤寡肽类药物研究进展[J].中国医药生物技术.2009,4(4):288一290. [29] 孙立春,COY David H.多肽药物研究进展[J].上海医药,2014,35(5):55一60. [30] Fang H,Luo M,Sheng Y,et al. The antihypertensive effect of peptides:a novel altemative to drugs?[J].Peptides,2008,29(6):1062一1071. [31] 聂彩辉,徐寒梅.多肽药物的发展现状[J].药学进展,2014,38(3):1:6一202. [32] 李晓玉.安泰胶囊的免疫增强和保肝作用[J].中国药理学通讯,1999,16(2):28一30.2023-07-30 04:47:401
陈芬儿的主要作品
代表著作1. F.E. Chen* and J. Huang, Reserpine: A Challenge for Total Synthesis of Natural Products, Chem. Rev.,2005,12,4671-47062. F.E.Chen*, X.X.Chen, H.F.Dai, Y.Y.Kuang, B.Xie, J.F.Zhao, Synthetic Studies on d-biotin, part 8: An Efficient Chemoenzymatic Approach to the Asymmetric Total Synthesis of d-Biotin via a Polymer-Supported PLE-Mediated Desymmetrization of meso-Symmetic Discarboxylic Esters, Adv. Synth. Catal.,2005,347,549-5543. L. Ji, F.E. Chen*, X.Q. Feng, E.D. Clercq, J. Balzarini, C. Pannecouque, Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 7. - Synthesis, Antiviral Activity, and 3D-QSAR Investigations of Novel 6-(1-naphthoyl) HEPT analogues, Chem. Pharm. Bull, 2006,54,1248-12534. L.Ji, F.E.Chen*,E.D.Clercq, J.Balzarini, C.Pannecouque,Synthesis and Anti-HIV Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors,J. Med. Chem.,2007,50,1778-17865. L.Ji,F.E.Chen*,B.Xie,E.D.Clercq, J.Balzarini, C.Pannecouque, Synthesis and Anti-HIV Activity Evaluation of 1-[(Alkyl or alkynyl or Alkyloxy)methyl]-5-Alkyl-6-(1-Naphthonyl)-2,4-Pyrimidinediones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Eur. J. Med. Chem.,2007,42,198-2042023-07-30 04:48:321
protein的解释是什么
protein的意思是:n.蛋白质。protein的意思是:n.蛋白质。protein的例句是用作名词(n.)Youneedmoreproteintobuildyouup.你需要增加蛋白质以增强体质。protein形容词:proteinaceous。一、详尽释义点此查看protein的详细内容n.(名词)蛋白(质)【化】朊adj.(形容词)蛋白质的二、双解释义n.(名词)[C][U]蛋白质substancefoundinmeat,eggs,fish,etc.thatisanimportantbody-buildingpartofthedietofhumansandanimals三、词典解释1.蛋白质Proteinisasubstancefoundinfoodanddrinksuchasmeat,eggs,andmilk.Youneedproteininordertogrowandbehealthy.e.g.Fishwasamajorsourceofproteinfortheworkingman.鱼肉曾是劳动者的主要蛋白质来源。e.g....ahighproteindiet.高蛋白饮食四、例句Youneedmoreproteintobuildyouup.你需要增加蛋白质以增强体质。Trytobalanceyourdietbyeatingmorefruitandlessprotein.多吃些水果,少摄入些蛋白质,使饮食均衡合理。Pulsesareagoodsourceofproteinforvegetarians.对于素食者来说,豆类食物是蛋白质的理想来源。Avegetariangetsproteinnotfrommeatbutfromitsanalogues.素食者所摄取的蛋白质不是来自肉类而是来自近似肉类的食物。五、常见句型用作名词(n.)ProteinsandDNAarepolymers.蛋白质和脱氧核糖核酸都是聚合体。Soybeansareveryrichinprotein.大豆含有丰富的蛋白质。六、词汇搭配proteinengineering蛋白质工程corpuscularprotein粒蛋白proteinmilk高蛋白乳nativeprotein天然蛋白,天然蛋白质...proteinsynthesis蛋白质合成proteinmetabolism蛋白质代谢酌,蛋白质...digestibleprotein消化性蛋白,可消化蛋...peripheralprotein周围蛋白fibrousprotein纤维状朊,纤维状蛋白...coatprotein外壳蛋白foreignprotein异种蛋白contractileprotein收缩蛋白,伸缩蛋白...vegetableprotein植物蛋白质conjugatedprotein结合蛋白proteinconcentrate蛋白质精料totalprotein总蛋白质simpleprotein单纯蛋白质proteinnitrogen蛋白质氮animalprotein动物蛋白,动物性蛋白...texturedvegetableprotein组织化植物蛋白质...七、词源解说☆1844年进入英语,直接源自法语的protine;最初源自古希腊语的proteios,意为第一要质。protein的相关临近词protest、protector、Proteina、proteins、proteinA、ProteinZ、proteinic、proteinc、proteinI、ProteinER、proteinoid、proteinsis点此查看更多关于protein的详细信息2023-07-30 04:48:471
DPAs是什么意思
DPAs[医][=Douglas" pouch aspirates]道格拉斯(氏)陷凹抽吸缩略语网络释义DPAs的全称:未分类的(6)Douglas" pouch aspirates 道格拉斯陷凹抽吸, 直肠子宫陷凹抽吸deep pelvic abscesses 深部盆腔脓肿dendritic polyphenylazomethines 树枝状多苯基甲亚胺depressive personality analogues 抑郁性人格类似体diagnostic pharmaceutical agents 诊断性药物试剂diphenylalkylamines 二苯烷基胺2023-07-30 04:48:561
曹松的代表性论著
以下为近期以第一作者或通讯作者在SCI发表的论文:2013年Novel Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles via a One-pot Three-Component Reaction of Boronic acids, Azides and Active methylene ketonesJian Zhang, Guanyi Jin, Senhan Xiao, Jingjing Wu,Song Cao*Tetrahedron, 2013, onlineNiCl2(PCy3)2-catalyzed hydrodefluorination of fluoroarenes with LiAl(O-t-Bu)3HJuan Xiao, Jingjing Wu, Wenwen Zhao,Song Cao*J Fluorine Chem, 2013, online2012年One-pot Three Component Synthesis of Polyfluoroarylated ArylacetatesviaVNSAr-SNArReactionYang Xiong, Jingjing Wu, Senhan Xiao,Song Cao*Chin J Chem2012, 30, 2747-2751(Invited,Dedicated to the 60th Anniversary of East China University of Science and Technology)One-Pot, Three-Component Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Starting from Primary AlcoholsGuanyi Jin, Jian Zhang, Dan Fu, Jingjing Wu,Song Cao*Eur J Org Chem, 2012, 5446-5449Synthesis ofunsymmetrical biaryl ethersthrough nickel-promotedcoupling ofpolyfluoroarenes with arylboronic acidsand oxygenJian Zhang, Jingjing Wu, Yang Xiong,Song Cao*Chem Commun, 2012, 48, 8553-8555Oxidation of benzylic methylenes to ketones with Oxone-KBr in aqueous acetonitrile under transition metal free conditionsLixia Yin, Jingjing Wu, Juan Xiao,Song Cao*Tetrahedron Letters, 2012, 53, 4418-4421Synthesis and Insecticidal Activities of Novel Analogues of Flubendiamide Containing a Hexafluoroisopropanol MoietyMingxi Wu, Wenwen Zhao, Guanyi Jin, Qingchun Huang,Song Cao*Chin J Chem2012, 30, 1310-1314(Invited, Dedicated to Professor Jun Zhou on the occasion of his 80th birthday)Highly efficient NiCl2/NiCl2(PCy3)2co-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydrideWenwen Zhao, Jingjing Wu,Song Cao*Adv Synth Catal, 2012,354(4), 574-578Synthesis of Difluoromethyl-Containing α-Acyloxycarboxamide Derivatives through a Passerini Reaction and DesulfonylationJingjing Wu, Wenwen Zhao,Song Cao*Eur J Org Chem, 2012, 1380–13872011年Synthesis of novelgem-difluoromethylene-containing 1,2,3-triazoles via click reactionWenwen Zhao, Hui Li, Jian Zhang,Song Cao*Chin J Chem2011,29,2763-2768(Invited, Dedicated to Professor Weiyuan Huang on the occasion of his 90th birthday)Nickel-Catalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride (Lithium Triethylborohydride)Jingjing Wu andSong Cao*ChemCatChem,2011, 3(10), 1582-1586Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylationJingjing Wu, Hui Li,Song Cao*Beilstein J Org Chem,2011, 7, 1070–1074(Invited, Thematic Series: Multicomponent Reaction)ZnCl2-catalyzed hydrodefluorination of gem-difluoromethylene derivatives with lithium aluminum hydrideJianhang Cheng, Jingjing Wu,Song Cao*Tetrahedron Letters, 2011, 52, 3481-3484Novel synthesis of difluoromethyl-containing 1,4-disubstituted 1,2,3-triazoles via a click-multicomponent reaction and desulfanylation strategyJian Zhang, Jingjing Wu, Li Shen, Guanyi Jin,Song Cao*Adv Synth Catal, 2011, 353(4), 580-584One-pot synthesis of difluoromethyl-containing dihydropyrimidinones catalyzed by Yb(PFO)3under solvent and dehydrating agent free conditionsMingxi Wu, Jinlong Yu, Wenwen Zhao, Jingjing Wu,Song Cao*J Fluorine Chem, 2011, 132, 155-159Non-catalytic conversion of C-F bonds ofgem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydrideunder room temperatureJingJing Wu, JianHang Cheng, Jian Zhang, Li Shen, XuHong Qian andSong Cao*Tetrahedron, 2011, 67,285-2882010年K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditionsLi Shen,Song Cao*, Jingjing Wu, Hui Li, Jian Zhang, Mingxi Wu, Xuhong Qian*Tetrahedron Letters, 2010, 51, 4866-4869A mild and efficient synthesis of monofluorinateda-lactam pseudopeptides via a novel dehydrofluorination of Ugi productsNianjin Liu,Song Cao*, Jingjing Wu, Li Shen, Jinlong Yu, Jian Zhang, Hui Li, Xuhong Qian*Mol Divers, 2010, 14, 501-506An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditionsHui Li, Jinlong Yu,Song Cao*, Li Shen, Mingxi Wu, Jianhang Cheng, Xuhong Qian*ScienceChinaChemistry, 2010, 53(7), 1509-1513Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Cachannels CaV1.3 and CaV1.2Che-Chien Chang,Song Cao, Soosung Kang, Li Kai, Xinyong Tian, Prativa Pandey, Sara F. Dunne, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman (第二作者)Bioorg Med Chem, 2010, 18, 3147-3158A General Strategy for Construction of Difluoromethyl Compound Library and its Application in Synthesis of Pseudopeptides bearing Terminal Difluoromethyl GroupJingjing Wu,Song Cao*, Nianjin Liu, Li Shen, Jinlong Yu, Jian Zhang, Hui Li and Xuhong QianOrg Biomol Chem, 2010, 8, 2386-2391Synthesis and Insecticidal Activity of Heptafluoroisopropyl-Containing Benzoylphenylurea StructuresJian Zhang, Xiuhong Tang, Isaac Ishaaya,Song Cao*, Jingjing Wu, Jinlong Yu, Hui Li, Xuhong QianJ Agric Food Chem,2010, 58(5), 2736-27402009年Multicomponent Reactions Based on Fluoro-ContainingBuilding BlocksJingjing Wu andSong Cao*Curr Org Chem, 2009, 13(18), 1791-1840(Invited, Guest Editor, Thematic Series: Multicomponent Reaction)A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridinesLi Shen,Song Cao*, Jingjing Wu, Jian Zhang, Hui Li, Nianjin Liu and Xuhong Qian*Green Chemistry,2009, 11, 1414-1420New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reactionNianjin Liu,Song Cao*Li Shen, Jingjing Wu, Jinlong Yu, Jian Zhang, Hui Li, Xuhong Qian*Tetrahedron Letters, 2009, 5, 1982-19852008年One-Pot Synthesis of Trifluoromethyl-Containing Pyrazoles via Sequential Yb(PFO)3- Catalyzed Three-Component Reaction and IBX-Mediated OxidationLi Shen, Jian Zhang,Song Cao*, Jinlong Yu, Nianjin Liu, Jingjing Wu, Xuhong Qian*Synlett2008, 19, 3058-3062Ytterbium (III) Perfluorooctanoate-catalyzed One-pot Three-component Synthesis of Fully Substituted Pyrazoles under Solvent-free ConditionsLi Shen,Song Cao*, Nianjin Liu,Jingjing Wu, Xin Feng, Xuhong Qian*Synlett2008, 9, 1341-1344One-Pot Three Component Synthesis of Heteroaryled arylacetates via VNSAr-SN Reaction using N-Methylpyrrolidone as General SolventSong Cao*, Jingjing Wu, Lina Li, Longjie Zhu, Jian Zhang, Jinlong Yu, Xuhong QianOrg Biomol Chem, 2008, 6 (7), 1293-1297Solvent-Free Ugi Four-Component Condensation: Application to Synthesis of Philanthotoxins-12 AnaloguesNianjin Liu,Song Cao*, Jingjing Wu, Jinlong Yu, Li Shen, Xin Feng and Xuhong Qian*Tetrahedron, 2008, 64(18), 3877-4142Synthesis of Thiohydantoins under One-Pot Three-Component Solvent-Free ConditionsSong Cao*, Longjie Zhu, Chuanmeng Zhao, Xiuhong Tang, Huajun Sun, Xin Feng, Xuhong QianMonatshefte fur Chemie, 2008, 139, 923-9262007-2001年An Efficient and Practical Method for the Synthesis of 1-(2,6-Difluorobenzoyl)-3-[2"-alkyl-3"- oxopyridazin-4"-yl]ureas as Potential Chitin Synthesis InhibitorsSongCao, Deli Lu, Chuanmeng Zhao, LinaLi,Qingchun Huang,XuhongQian*Monatshefte fur Chemie, 2006, 137(6), 779-784Syntheses, Antifeedants and QSAR Analysis of New Oxa(thia)diazolyl 3(2H)-PyridazinonesSong Cao, Na Wei, Chuanmeng Zhao, Lina Li, Qingchun Huang, Xuhong Qian*J of Agric and Food Chem, 2005, 53, 3120-3125Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-PyridazinonesSong Cao, Xuhong Qian*, Gonghua Song, Bing Chai, Zhisheng JiangJ of Agric and Food Chem, 2003, 51, 152-155Synthesis of 3-Aryl-1,3,5-pentanetricarboxylic acid trialkyl esters via a Tandem Addition- Rearrangement-Addition ReactionSong Cao*, Zheng Zhang, Ai-Long Fan,Zi-Ming HuangMonatshefte fur Chemie, 2003, 134, 529-532Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl)-1,3,4– oxadiazolesSong Cao, Xuhong Qian*, Gonghua Song, Qingchun HungJ of Fluorine Chem, 2002, 117, 63-66N"-tert-butyl-N"-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines, A Novel Nonsteroidal Ecdysone Agonist: Syntheses , Conformational and Crystal Structure AnalysisSong Cao, Xuhong Qian*, Gonghua SongCanadian J of Chem, 2001, 79, 272-278A Novel and Practical Amination of 4,5-Dichloropyridazinones via Hydrazine Hydrate ReductionSong Cao, Xuhong Qian*, Gonghua Song, Xiayu HuangChemistry Letters, 2001, 1, 54-552023-07-30 04:49:151
【神奇的小分子活性肽】第一章小分子肽·第四节小分子肽的营养吸收机制
传统的蛋白质营养理论认为,动物摄入蛋白质首先在消化道内经过蛋白酶等内切酶的作用降解为分子量较小的寡肽,寡肽再经羧肽酶和氨肽酶等外切酶的作用生成游离氨基酸而被吸收利用,在此过程中,肽仅仅是蛋白质消化过程的中间产物,并没有特殊的营养意义。 Agar(1953年)首先证实了肠道能完整吸收双甘肽,但是由于受传统蛋白质消化吸收理论的影响,学者们对其他吸收方式不容易接受,并且由于双甘肽被认为是一种特殊的2肽,它的分子量很小,因此这一发现的重要性没有被认识到,直到20世纪60年代,Newey等第一次提出小肽被完整吸收的观点。Hara等(1984年)在小肠黏膜细胞上发现小肽载体,进一步证实小肽能完整地通过小肠黏膜细胞直接进入循环。20世纪90年代,小肽载体被克隆,小肽的吸收机制才逐渐被人们所认识。 已知的研究发现, 小分子肽的营养吸收机制至少具有以下十大特点: (1)小分子肚不需消化,可以直接吸收。 传统上人们认为,只有游离氨基酸才能被动物直接吸收利用。近年来的研究表明,蛋白质在消化道中的消化终产物的大部分往往是小肽,而且小肽能完整地通过肠黏膜细胞进入人体循环。 (2)小分子肽吸收快速,耗能低且载体不易饱和。 研究发现,哺乳动物对肽中的氨基酸残基的吸收速度大于对游离氨基酸的吸收速度。Hara等(1984年)发现,大鼠对蛋白酶降解产生的氨基酸吸收强度比相应游离氨基酸高70%~80%。Daneil等(1994年)认为肽载体吸收能力可能高于各种氨基酸载体吸收能力的总和。实验证明,小分子肽比氨基酸更易、更快地被机体吸收利用,并且不受抗营养因子的干扰。 (3)小分子肽具有百分之百被人体吸收的特点。 与游离氨基酸相比,小分子肽的吸收不仅迅速,而且吸收效率高,几乎全部被机体吸收。 (4)小分子肽以完整的形式吸收。 小分子肽在肠道中不易进一步水解,能较完整地吸收进入血液循环。血液循环中的小肽能直接参与组织蛋白质的合成,此外,肝脏、肾脏、皮肤和其他组织也能完整地利用小肽。 (5) 小分子肽的转运机制与氨基酸的转运机制有很大不同,在吸收过程中,不存在与氨基酸转运相互竞争载体或拮抗的问题。 已知 小分子肽存在三种转运系统: 第一种,是具有pH依赖的H+/Na+交换转运体系,不消耗ATP; 第二种,是依赖H+或Ca2+钙离子浓度的主动转运过程,需要消耗ATP; 第三种,是通过谷胱甘肽(GSH)结合的转运系统。 (6) 由于避免了游离氨基酸在吸收时的竞争,小分子肽可以使摄入的氨基酸更加平衡,提高了机体蛋白质的合成效率。对于消化系统未发育成熟的婴幼儿,对于消化系统开始退化的老年人,对于急需补充氮源而又不能增加胃肠功能负担的运动员,对于那些消化能力差、营养缺乏、身体虚弱、体弱多病者,若以小肽的形式补充氨基酸,可以改善氨基酸的吸收,满足机体对氨基酸和氮的需求。 (7)小分子肽可促进对氨基酸的吸收。 如当赖氨酸和精氨酸以游离形式存在时,两者相互竞争吸收位点,游离精氨酸有降低肝门静脉赖氨酸水平的倾向,而以肽形式存在时,则对赖氨酸的吸收无影响。以小分子肽与氨基酸的混合物形式吸收是人体吸收蛋白质的最佳吸收机制。Lenoard等(1976年)研究表明,患有遗传性氨基酸代谢病的患者不能吸收游离的中性氨基酸,但是可以吸收肽结合的中性氨基酸。 (8)小分子肽可以促进矿物质的吸收。 小分子肽可与钙、锌、铜、铁等矿物离子形成螯合物增加其可溶性,有利于机体的吸收。研究证明,在生物体消化过程中形成的酪蛋白磷酸肽(CPPS)可促进钙、铁、锌、锰、铜、镁、硒等的吸收。这是因为钙、铁等金属离子必须在小肠黏膜上处于溶解状态时才能有效地被机体吸收。然而小肠环境偏碱性,钙、铁易与磷酸形成不溶性盐,从而大大降低了钙、铁的吸收率。CPPS可与钙、铁等金属离子形成可溶性复合物,在小肠中使可溶性钙、铁浓度提高,从而增强肠道对钙、铁的吸收。 (9) 小分子肽被人体吸收后,可以直接作为神经递质,间接刺激肠道受体激素或酶的分泌而发挥作用。 (10)小分子肽可以促进肠道黏膜结构和功能发育。 小分子肽可优先作为肠道黏膜上皮细胞结构和功能发育的能源底物,有效促进肠道黏膜组织的发育和修复,从而维持肠道黏膜的正常结构和机能。 参考文献 [1] 李勇.肽临床营养学[M].北京:北京大学医学出版社,2012. [2] 冯秀燕,计成.寡肽在蛋白质营养中的作用[j].动物营养学报,2001,13(3):8-13. [3] Agar WT,Hird F J,Sidhu G S. The active absoption of amino-acids by the intestine[J].Physiol.,1953,121(2):255一263. [4] Neway H,Smith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J].Physiol.,1996,152:367一380. [5] Daniel H. Molecular and Integrative PhysioI0gy of Intestinal Peptide Transport[J].Annual Rev. Physiol.,2004,66:361一384. [6] zaloga G P . Physiologic effects of peptides based enternal formulae[J].Nutrition in cIinical practice,1990,5:231—237. [7] Hara H,Funabili M,Iwata,et al . Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr.,1984,114:1122—1129. [8] Leonard J V,Marrs T C,Addison J M,et al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J].Pediatr Res.,1976,10(4):246—249 [9] 李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014,26(1):17一25. [10] 王春艳,田金强,王强.改善心血管健康的食源性生物活性肽构效关系研究进展[J].食品科学,2010,31(13):307一311. [11] 李世敏.食源性活性多肽与降血压研究进展日[J].老年医学保健,2008,14(2):125一127. [12] Dziuba J,Minkiewicz P,Nalecz D,et al. Database of biologically active peptide sequences[J].Nattrunges.,1999,43:190—195.‘ [13] Shin Z,Yu R,Park S A,et al. His-His-Leu ,an angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste,exerts arltihyPertensive activity in vivo[J].J Agric Food chem.,2001,49(6):3004一3009. [14] Hirasawa M , Shijubo N,Uede T,et al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J].Br J Cancer.,1994,70(3):466—473. [15] Florentin l,Chung V,Martinez J,et al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J].Methods Find Exp Clin Pharmacol.,1986,8(2):73—80. [16] Tsuchita H,Suzuki T,Kuwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J].Br J Nutr.,2001,85(1):5一10. [17] 张昊,任发政.天然抗氧化肽的研究进展[J].食品科学,2008,29(4):443一447. [18] 张莉莉,严群芳,王恬.大豆生物活性肽的分离及其抗氧化活性研究[J].食品科学,2007,28(5):208一211. [19] 荣建华,李小定,谢笔钧.大豆肽体外抗氧化效果的研究[J].食品科学,2002,23(11):118一120. [20] 崔剑,李兆陇,洪啸莺吟.自由基生物抗氧化与疾病[J].清华大学学报自然科学版,2000,40(6):9一2. [21] 陆融,王卓.小分子多肽抗肿瘤作用的研究进展[J].天津医科大学学报,2005,11(3):499一502. [22] Chène P,Fuchs J,Bohn J,et al. A small synthetic peptide , which inhibits the p53-hdm2 interaction,stimulates the p53 pathway in tumour cell lines[J].J Mol Biol.,2000,299(1):245一253. [23] Issaeva N,Friedler A,Bozko P,et al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J].Proc Natl Acad Sci USA.,2003,100(23):13303一13307. [24] 朱维铭.临床营养角色的转变:从营养支持到解怡疗[J].肠外与肠内营养,2009,16(1):1—3l. [25] 裴新荣,杨奋悦,张召锋,等.海洋胶原肽抗皮肤老化作用的实验研究[J].中华预防医学杂志,2008,42(4):235—238. [26] 梁锐,张召锋,赵明,等.海洋胶原肽对剖宫产大鼠伤口愈合促进作用[J].中国公共卫生,2010,26(9):1144一1145. [27] 王竹青,李八方.生物活性肽及其研究进展[J].中国海洋药物杂志,2010,29(2):60一68. [28] 何平均.抗肿瘤寡肽类药物研究进展[J].中国医药生物技术.2009,4(4):288一290. [29] 孙立春,COY David H.多肽药物研究进展[J].上海医药,2014,35(5):55一60. [30] Fang H,Luo M,Sheng Y,et al. The antihypertensive effect of peptides:a novel altemative to drugs?[J].Peptides,2008,29(6):1062一1071. [31] 聂彩辉,徐寒梅.多肽药物的发展现状[J].药学进展,2014,38(3):1:6一202. [32] 李晓玉.安泰胶囊的免疫增强和保肝作用[J].中国药理学通讯,1999,16(2):28一30.2023-07-30 04:49:311
张贵生的论文专利
1、书籍1.WenlanChen,GuishengZhang,LizhiZhu,LanyanFang,XianhuaCao,JamesKedenburg,JieShen,DuxinSun,andPengGeorgeWang,UncommonSugarsandTheirConjugatestoNaturalProducts.《FrontiersinModernCarbohydrateChemistry》,Chapter2,2007,pp15-33;ACSSymposiumSeries,Volume960.PublicationDate(Print):March13,2007(Chapter)DOI:10.1021/bk-2007--0960 ch002.2、论文1.LingjunLi,RanLi,AnlianZhu,GuishengZhang,LiheZhang,CuBr-NCS-mediatedazide-alkynecycloaddition:mildandeffientsynthesisof5-bromo-1,4-disubstituted-1,2,3-triazoles,Synlett,2011,6,874-878.2.XiaoyunDang,QingfengLiu,FenglingCui,LixiaQin,GuishengZhang*,XiaojunYao,JuanDu,Animprovedsyntheticapproachto7-[3-amino-4-O-(α-l-mycarosyl)-2,3,6-trideoxy-α-l-lyxo-hexopyranosyl]daunorubicinoneanditsinteractionwithhumanserumalbumin.CarbohydrateResearch,2011,346,949-955.3.JianpingLi,JikuanJiu,HuijuanLi,GuishengZhang,Anefficientthree-componentone-potpreparationof1,4-dihydropyridinescontainingnovelsubstitutedpyrazoleundersulfamicacidcatalysis.Chin.J.Chem.,2011,29,511-514.4.YanLu,JuanLv,GuishengZhang,GongkeWang,QingfengLiu,InteractionofananthracyclinedisaccharidewithctDNA:Investigationbyspectroscopictechniqueandmodelingstudies.SpectrochimicaActaPartA,2010,75,1511-1515.5.XiaopengZhang,HuanzhiJingandGuishengZhang,Selenium-catalyzedoxidativecarbonylationofanilineandalcoholstoN-phenylcarbamates.Synth.Commun.,2010,40,1614-1624.6.YanLu,QingqinFeng,FenglingCui,WeiweiXing,GuishengZhang,*XiaojunYao.Interactionof3`-azido-3`-deaminodaunorubicinwithhumanserumalbumin:Investigationbyfluorescencespectroscopyandmolecularmodelingmethods.Bioorg.Med.Chem.,2010,20(23),6899-6904.7.HaimingGuo,ZhijieMao,ARKIVOC,2010(ix)300-307.HongyingNiu,DongchaoWang,GuishengZhangandGuirongQu,Improvedone-potsynthesisof6-methylpurinesundermicrowaveirradiation.8.ZhiguoHu,*XiaoshanFan,GuishengZhang,Synthesisandcharacterizationofglucose-graftedbiodegradableamphiphilicglycopolymersP(AGE-glucose)-b-PLA.Carbohydr.Polym.,2010,79,119-124.9.LingjunLi,JiuxiaWang,GuishengZhang*,QingfengLiu,Amildcopper-mediatedGlaser-typecouplingreactionunderthenovelCuI/NBS/DIPEApromotingsystem,TetrahedronLett.,2009,50,4033.10.FenglingCui,XiaoduoKong,LixiaQin,GuishengZhang*,QingfengLiu,BeileiLei,XiaojunYao,Specificinteractionof4′-O-(a-l-Cladinosyl)daunorubicinwithhumanserumalbumin:ThebindingsiteIIonHSAmolecularusingspectroscopyandmodeling,J.Photochem.Photobio.B,2009,95(3),162-169.11.FenglingCui,LixiaQin,GuishengZhang,*XiaojunYao,BeileiLei,StudyoftheInteractionofAglyconofDaunorubicinwithHumanSerumAlbuminbySpectroscopyandModeling,MacromolBiosci,2008,8,1079-1089.12.FenglingCui,LixiaQin,GuishengZhang,*QingfengLiu,XiaojunYao,BeileiLei,Interactionofanthracyclinedisaccharidewithhumanserumalbumin:Investigationbyfluorescencespectroscopictechniqueandmodelingstudies,J.Pharma.Biomed.Anal.,2008,48,1029-1036.13.FenglingCui,LixiaQin,GuishengZhang,*XiaobingLiu,XiaojunYao,BeileiLei,Aconciseapproachto1,11-didechloro-6-methyl-4`-O-demethylrebeccamycinanditsbindingtohumanserumalbumin:Fluorescencespectroscopyandmolecularmodelingmethod,Bioorg.Med.Chem.,2008,16,7615-7621.14.LingjunLi,GuishengZhang,*AnlianZhuandLiheZhang,Aconvenientpreparationof5-Iodo-1,4-disubstituted-1,2,3-triazole:multi-componentone-potreactionofazideandalkynemediatedbyCuI-NBS,J.Org.Chem.,2008,73(9),3630-3633.15.LeiShi,GuishengZhang*andFengPan,Fe2(SO4)3·xH2O-catalyzedper-O-acetylationofsugarscompatiblewithacid-labileprotectinggroupsadoptedincarbohydratechemistry,Tetrahedron,2008,64,2572-2575.16.FenglingCui,LixiaQin,GuishengZhang,XiaojunYao,JuanDu,Bindingofdaunorubicintohumanserumalbuminusingmolecularmodelinganditsanalyticalapplication.Int.J.Biol.Macromol.,2008,42,221-228.17.GuishengZhang*,QingfengLiu,LeiShi,JiuxiaWang,Ferricsulfatehydrate-catalyzedO-glycosylationusingglycolswithorwithoutmicrowaveirradiation,Tetrahedron,2008,64,339-344.18.GuishengZhangandQingfengLiu.Ferricsulphatehydrate-catalyzed,microwave-assistedsynthesisof2,3-unsaturatedO-glycosidesviatheFerrierreaction.Synth.Commun.,2007,37,3485-3492.19.GuishengZhang,*LeiShi,QingfengLiu,J.Wang,L.LiandX.Liu.Adivergentstrategyforconstructingasugarlibrarycontaining2,6-dideoxysugarsanduncommonsugarswith4-substitution.Tetrahedron,2007,63,9705-9711.20.G.Zhang,L.Shi,Q.Liu,X.Liu,L.LiandJ.Wang,Adivergentapproachto3-azido-2,3,6-trideoxy-L-hexosesfromrhamnal,TetrahedronLett.,2007,48,3413-341621.D . Lu,J.Nadas,G.Zhang,W.Johnson,J.L.Zweier,A.J.Cardounel,F.A.Villamena,andP.G.Wang,4-Aryl-1,3,2-oxathiazolylium-5-olatesaspH-ControlledNO-Donors:TheNextGenerationofS-Nitrosothiols,J.Am.Chem.Soc.,2007,129(17),5503-5514.22.R.F.Battisti,Y.Zhong,L.Fang,S.Gibbs,J.Shen,J.Nadas,G.ZhangandD.Sun,ModifyingthesugarmoietiesofdaunorubicinovercomesP-gp-mediatedmultidrugresistance.MolecularPharmaceutics,2007,4(1),140-153.23.ChangshengZhang,ChristophAlbermann,XunFu,NoelR.Peters,JohnD.Chisholm,GuishengZhang,EricJ.Gilbert,PengGeorgeWang,DavidL.VanVrankenandJonS.Thorson*,RebG-andRebM-catalyzedindolocarbazolediversification.ChemBioChem,2006,7,795-804.24.G.Zhang,L.Fang,L.Zhu,Y.Zhong,P.G.Wang,D.Sun,Synthesesandbiologicalactivitiesof3-azidodisaccharideanaloguesofdaunorubicinagainstdrug-resistantleukemia.J.Med.Chem.,2006,49(5),1792-1799.25.L.Fang,G.Zhang(co-firstauthor),C . Li,uf020X.Zheng,L.Zhu,J.J.Xiao,G.Szakacs,J.Nadas,K.K.Chan,P.G.Wang,D.Sun,DiscoveryofadaunorubicinanaloguethatexhibitspotentantitumoractivityandovercomesP-gp-mediateddrugresistance.J.Med.Chem.,2006,49(3),932-941.26.Zhang,G.;Fang,L.;Zhu,L.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivityofbisdaunorubicins.Bioorg.Med.Chem.,2006,14(2),426-434.27 .Li,L.;Zhu,L.;Zhang,X.;Zhang*,G.;Qu,G.,Convenienttetrahydropyranylationofalcoholsandphenolsbycatalyticferricsulfatehydrate(Fe2(SO4)3·xH2O).Can.J.Chem.,2005,83(8),1120-1123.28.Zhang,G.;Shen,J.;Cheng,H.;Zhu,L.;Fang,L.;Luo,S.;Muller,M.T.;Lee,G.E.;Wei,L.;Du,Y.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivitiesofrebeccamycinanalogswithuncommonsugars.J.Med.Chem.,2005,48(7),2600-2611.29. Ye,X.-S.;Sun,F.;Liu,M.;Li,Q.;Wang,Y.;Zhang,G.;Zhang,L.-H.;Zhang,X.-L.,Syntheticiminosugarderivativesasnewpotentialimmunosuppressiveagents.J.Med.Chem.,2005,48(11),3688-3691.30.Luo,S.;Zhu,L.;Talukdar,A.;Zhang,G.;Mi,X.;Cheng,J.-P.;Wang,P.G.,Recentadvancesinrareearth-metaltriflatecatalyzedorganicsynthesisingreenmedia.Mini-ReviewsinOrganicChemistry,2005,2(2),177-202.31.Zhu,L.;Talukdar,A.;Zhang,G.;Kedenburg,J.P.;Wang,P.G.,ADivergentsynthesisofuncommonsugarsfromfuranaldehyde.Synlett,2005,10,1547-1550.32.Zhang,G.;Fang,L.;Zhu,L.;Aimiuwu,J.E.;Shen,J.;H.,C.;Muller,M.T.;Lee,G.E.;Sun,D.;Wang,P.G.,SynthesesandBiologicalActivitiesofDisaccharideDaunorubicins.J.Med.Chem.,2005,48,5269-5278.33.Zhu,L.;Cao,X.;Chen,W.;Zhang,G.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivitiesofdaunorubicinanalogswithuncommonsugars.Bioorg.Med.Chem.,2005,13,6382-6387.3、专利1.Multidrugresistanceanticanceranthracyclines.USPatent20060276418A1。2.Multidrugresistanceanticanceranthracyclines.PCT/US2006/018630;WO2006124720A1。3.多重耐药抗癌药蒽环类,200680016329.04.一种用于化学反应过程中的新型分水器,ZL201020181503.0,5.一种简单、高效、合成4-取代恶唑烷酮衍生物的方法,201010264733.8,。6具有抗癌活性的蝴蝶霉素类似物及合成方法,201010569632.1。7具有抗癌活性的蒽环类抗生素简单结构类似物及制备方法,201010569901.4。8具有抗癌活性的3"-叠氮基表阿霉素的合成,201110023054.6。9(S)-2-羟烷基-1,4-二羟基-9,10-蒽醌与糖基缀合物的合成及抗肿瘤活性201110023502.2。2023-07-30 04:49:391
娄红祥的学术科研
作为课题负责人他先后承担:国家自然科学基金4项,教育部重点科研课题,教育部优秀青年资助计划课题,教育部留学回国启动基金、山东省重点科研课题等多项,与企业合作开展的新药研发课题多项。开展了多酚类化合物等抗氧化剂与糖尿病并发症预防方面的深入研究;中国苔藓植物化学成分系统研究,对苔藓植物抗真菌、抗真菌耐药等进行了较系统的研究,有许多新的发现和突破。已完成了近40种动植物活性化合物的研究工作,发现新结构化合物100多个,发表学术论文90余篇,SCI引用近20篇。已经获得新药证书的新药3项,获得批准进行临床研究的新药5项,临床待批的新药4项,进行中的新药4项,申请中的专利9项。承担课题:国家杰出青年基金:“苔藓植物化学成分与生物学活性意义研究”(2010)国家基金重点项目:“苔藓植物中抗真菌活性成分的高通量发现与衍生物制备”(2008)国家重大新药创制综合大平台 (2009)主编出版《苔藓化学与生物学》(科学技术出版社,2012), 译著《药用天然产物生物合成》(Paul M Dewick,化学工业出版社 2008)。在国际刊物Org Lett, Nat Prod Rep, J Nat Prod, Phytochem, Cancer Lett, Bio Med Chem, ChemBiochem,Plos One等发表SCI文章近150篇,他引超过1000次;授权中国专利9项,申请美国专利1项。为主承担的两项新药研究获得新药证书,三个新药研发项目取得临床批件。 科研方向:活性天然产物研究和新药开发1. 从苔藓植物和药用植物中发现活性萜类、多酚和生物碱类化合物2. 天然产物的抗真菌、抗肿瘤和抗氧化活性机制研究3. 天然抗氧化剂的心血管系统保护作用研究 1. 苔藓植物中抗真菌耐药有效成分的高通量发现与衍生物制备 国家自然科学基金重点项目(No. 30730109), 项目负责人2. 苔类植物联苄类化合物抗真菌及逆转真菌耐药机制研究 国家重点基础研究发展计划(973计划)课题(No. 2006CB708511), 项目负责人3. 苔类植物成分抑制真菌生物被膜形成及逆转耐药的研究 国家自然科学基金项目(No. 30672531), 项目负责人4. 原花青素诱导心肌细胞内源性抗氧化剂分子机理和抗氧化性损伤的研究 国家自然科学基金项目(No. 30472072), 项目负责人5. 基于糖识别的重大疾病耐药逆转剂的研究 山东省自主创新重大科技专项计划(No. 2006GG1102023), 项目负责人6. 抗肝炎药物生物碱-有机酸复盐的研制 山东省科技攻关项目(No. Y2006C38), 项目负责人 1. Ren Dong-Mei, Guo Huai-Fang, Wang Shu-Qi, Lou Hong-Xiang*. Separation and structure determination of two diastereomeric pairs of enantiomers from Dracocephalum rupestre by high-performance liquid chromatography with circular dichroism detection. Journal of Chromatography A, 2007, 1161: 334uf02d337.2. Ma Bin, Guo Huai-Fang, Lou Hong-Xiang*. A new lignan and two eudesmanes from Lepidozia vitrea. Helvetica Chimica Acta 2007, 90: 58uf02d62.3. Ma Bin, Lu Zhi-Qiang, Guo Huai-Fang, Lou Hong-Xiang*. Rearranged calamenene and eudesmane sesquiterpenoids from two Chinese liverworts. Helvetica Chimica Acta 2007, 90: 52uf02d57.4. Xie Chun-Feng, Qu Jian-Bo, Sun Bin, Guo Huai-Fang, Lou Hong-Xiang*. Dumhirone A, an unusual phenylethyl cyclohexadienone from the Chinese liverwort Dumortiera hirsuta. Biochemical Systematics and Ecology 2007, 35: 162uf02d165.5. Shen Tao, Wan Wen-Zhu, Yuan Hui-Qing, Kong Feng, Fan Pei-Hong, Lou Hong-Xiang*. Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells. Phytochemistry 2007, 68: 1331uf02d1337.6. Qu Jian-Bo, Xie Chun-Feng, Guo Huai-Fang, Lou Hong-Xiang*. Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta. Phytochemistry 2007, 68: 1767uf02d1774.7. Xing Jie, Xie Chun-Feng, Lou Hong-Xiang*. Recent applications of liquid chromatography–mass spectrometry in natural products bioanalysis. Journal of Pharmaceutical and Biomedical Analysis 2007, 44: 368uf02d378.8. Zhan Tian-Rong, Lou Hong-Xiang*. Synthesis of azole nucleoside analogues of d-pinitol as potential antitumor agents. Carbohydrate Research 2007, 342: 8695uf02d8699.9. Qu Jian-Bo, Xie Chun-Feng, Ji Mei, Shi Yan-Qiu, Lou Hong-Xiang*. Water-soluble constituents from the liverwort Marchantia polymorpha. Helvetica Chimica Acta, 2007, 90: 2109uf02d2115.10. Zhao Gui-Sen, Liu Chuan, Wang Rui, Song Dan-Dan, Wang Xiao-Bing, Lou Hong-Xiang*, Jing Yong-Kui*. The synthesis of α,β-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S-transferase P1-1 activity and the proliferation of leukemia cells. Bioorganic & Medicinal Chemistry 2007, 15: 2701uf02d2707.11. Fang Lei, Guo Huai-Fang, Lou Hong-Xiang*. Three new bibenzyl derivatives from the Chinese liverwort Marchantia polymorpha L. Helvetica Chimica Acta 2007, 90: 748uf02d752.12. Xing Jie, Xie Chun-Feng, Qu Jian-Bo, Guo Huai-Fang, Lv Bei-Bei, Lou Hong-Xiang*. Rapid screening for bisbibenzyls in bryophyte crude extracts using liquid chromatography/ tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007, 21: 2467uf02d2476.13. Guo Huai-Fang, Xing Jie, Xie Chun-Feng, Qu Jian-Bo, Gao Yan-Hui, Lou Hong-Xiang*. Study of bis(bibenzyls) in bryophytes using electron ionization time-of-flight and electrospray ionization triple-quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry 2007, 21: 1367uf02d1374.14. Yu Bei-Bei, Han Xiu-Zhen, Lou Hong-Xiang*. Oligomers of resveratrol and ferulic acid prepared by peroxidase-catalyzed oxidation and their protective effects on cardiac injury. Journal of Agricultural and Food Chemistry 2007, 55: 7753–7757.15. Du Yu, Guo Huai-Fang, Lou Hong-Xiang*. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. Journal of Agricultural and Food Chemistry 2007, 55: 1695uf02d1701. 1. 娄红祥, 王小宁. 苔藓植物化学成分研究. 天然产物化学进展; 于德泉, 吴毓林 主编; 化学工业出版社: 北京, 2005年; pp 251uf02d300.2. 娄红祥 主编, 苔藓植物化学和生物学. 北京科学技术出版社: 北京, 2006年; pp 1uf02d363..3. 娄红祥, 范培红. 鞣质. 实用天然有机产物化学; 吴立军 主编; 人民卫生出版社: 北京, 2007年; pp 946-983.4. 联苄类化合物13,13uf0a2-O-异丙叉基片叶苔素D及其提取分离方法与应用5. 姜黄素磷脂复合物及其制备方法6. 一种联苄类化合物羽苔素E及其提取分离方法与应用7. 乙酰水杨酰基葛根素衍生物及其制备方法及应用8. 一种治疗心脑血管系统疾病的总黄酮及其制备方法与应用2023-07-30 04:49:521
李忠的2007年-今代表性论著
1.Feng Fan,Jiagao Cheng, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Novel dimer based descriptors with solvational computation for QSAR study of oxadiazoylbenzoyl-ureas as novel isect-growth regulators”.Journal of Computational Chemistry.2009, published online,DOI: 10.1002/jcc.21352.Feng Fan, Zhiqi You,Zhong Li*, Jiagao Cheng, Yun Tang, Zhenhua Tang.“A Butterfly Effect: Highly Insecticidal Resistance Caused by Only a Conservative Residue Mutated of Drosophila Melanogaster Acetylcholinesterase”.Journal of Molecular Modeling,2009,15, 1229-12363.Xusheng Shao,Zhong Li*, Xuhong Qian, Xiaoyong Xu*. “Design, Synthesis, and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitroconjugated System”.J. Agric. Food Chem.2009,57,951–9574.Xusheng Shao, Wenwen Zhang, Yanqing Peng,Zhong Li*, Zhongzhen Tian, Xuhong Qian *, “cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine”,Bioorg. Med. Chem. Lett.,2008,18, 6513-6516.5.Xiaobao Yang, Hongbin Zhai,*Zhong Li*, “Enantiocontrolled Synthesis of (-)-9-epi- Pentazocine and (-)-Aphanorphine”.Org. Lett.,2008,10, 2457–2460.6.Xiaobao Yang, Li Zhu,Yuedong Zhou,Zhong Li*, Hongbin Zhai*, “Efficient Synthesis of Monosubstituted 3-Alkynylfurans via Suzuki Coupling”,Synthesis,2008, (No.11), 1729–1732.7.XiaobaoYang, Bin Cheng,Zhong Li*, Hongbin Zhai*, “Formal Asymmetric Synthesis of (–)-Aphanorphine via Ring- Closing Metathesis Reaction”,SYNLETT,2008,(No.18),2821-2822.8.Shaoyong Ke,Zhong Li, Xuhong Qian*, “1,3,4-Oxadiazole-3(2H)- carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety”.Bioorg. Med. Chem.,2008,16, 7565–7572.9.Chuanxiang Liu, Xuhong Qian,* Guangqiang Sun, Liwei Zhao andZhong Li*, Chromogenic and fluorescent chemodosimeter for fluoride ion based on novel anion-catalyzed intramolecular hydrogen transfer,New J. Chem.,2008,32, 472-476.10.Chuanxiang Liu, Xuhong Qian*, Jiaobing Wang,Zhong Li*, Anion recognition by a novel Fipronil-based receptor: efficient deprotonation or stable intermolecular hydrogen bonding,Tetrahedron Lett.,2008,49, 1087-1090.11.Ming-Yi Cai,Zhong Li*, Qingchun Huang, and Gonghua Song*“{[1-(Arylmethyl) piperidin-4-yl]oxy} -(trifluoromethyl)- pyridines: Ketanserin Analogues with Insect Growth Regulating Activity”Chem. Biodivers,2008, 1844-1855.12.Yanli Wang, Jiagao Cheng, Xuhong Qian*,Zhong Li*. “Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: Hydrogen bonding and cooperativeπ—πinteraction”.Bioorgan. Med.Chem.2007,15, 2624-2630.13.Feng Fan,Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Quantitative Aggregation- Activity Relationship (QAAR): Supermolecular view, dimer as the simplest aggregation state and monomolecule.”QSAR & Combinatorial Science,2007,26, 737-743.14.Zhongzhen Tian, Zhaoxing Jiang,Zhong Li*, Gonghua Song*, Qingchun. Huang. “Syntheses and Biological Activities of octahydro-1H-cyclopenta[d] pyrimidine derivatives”.J. Agric. Food Chem.,2007,55, 143-147.15.ZhongzhenTian, Xusheng Shao,Zhong Li*, Xuhong Qian*, Qingchun Huang, “Synthesis, Insecticidal Activity, and QSAR of Novel Nitromethylene Neonicotinoids with Tetrahydropyridine FixedcisConfiguration and Exo-Ring Ether Modification”,J. Agric. Food Chem.,2007,55, 2288-2292.2023-07-30 04:50:151
汪波的发表论文
1 汪波,李瑞声,龙康侯 3-甲基-3-丁烯-1-醇溴代的新方法 中山大学学报 1996, 35 (3), 1172 季凤英,汪波,王希林,许遵乐 1,1"-联-2-萘酚双醚的合成 中山大学学报 1996, 35 (3), 1203 刘汉标,汪波,季凤英,许遵乐 光活性胺的合成和拆分 中山大学学报 1996, 35 (5), 734 汪波,李瑞声,龙康侯 海洋天然产物倍半萜醇Capnellenol的研究Ⅰ 二环中间体4,7,7-三甲基二环[3,3,0]辛烷酮的合成 中山大学学报 1996, 35 (6), 105 许遵乐,蔡敏,汪波,刘汉标 手性2,5-双 恶唑啉 塞吩的合成和应用研究 中山大学学报 1996, 35 (6), 1316 李瑞声,温文坚张维汉,汪波,邓一军 中国南海软珊瑚Nephthea Bayeri的化学成分研究----一种类脱皮激素五羟基甾醇的分离鉴定 中山大学学报 1996, 35 (6), 17 蒲含林,汪波,朱可佳,郑其煌 简便连续加压柱层析 化学通报 1996, 11, 518 汪波,梁志博,刘正阳,许遵乐 N-取代-1,8-萘二甲酰亚胺类荧光物的合成 中山大学学报 1997, 36(2),729 许遵乐,陈叶荣汪波,刘汉标,钟增培 芳并呋喃类化合物的一锅化合成法 有机化学 1997, (17)4,33510 汪波,李瑞声 结构新颖的三并五元环倍半萜Capnellene及Cap-nellenols 的全合成综述 合成化学 1997, 5(2),14711 李瑞声,温文坚汪波 中国南海软珊瑚Nephthea Bayeri的化学成分研究--19-羟基-24-亚甲基多羟基甾醇的分离鉴定 中国海洋药物 1996, 15(4), 512 Wang Bo, JI Fengying, Zhong Zengpei, Liu Hanbiao, Xu Zunle KF Used as Reagents in O-alkylization of 1,1"-Bi-2-naphthol 第五届欧亚化学会议论文摘要,广州 1996,1213 P. V. Ramachandran B. Wang, H. C. Brown Asymmetric Enolboration-Aldolization of Fluorocarbonyl Compounds 15th International Symposium on Fluorine Chemistry,Vancouver, Canada, August 2-7, 1997 199714 B. Wang, Stereoselctive Enolboration-Aldolization and Asymmetric Reduction of a-Azidoketone 3rd Herbert C. Brown Special Symposium, Purdue, USA, April 4-5, 1997 199715 谭端明,李惠华,刘汉标,汪波,许遵乐 Cu(II)-胺络合物试剂作用下的新型氧化偶合反应 广东省化学会第六届学术年会论文集,1998年12月,汕头 199816 汪波,季凤英,许遵乐 寓科研意识的培养于基础课教学中 改革与实践(六),中山大学出版社 1999年,1017 陆慧宁, 刘汉标, 汪波, 陈浩林, 朱可佳, 段桂嫦 完善实验考核制度, 提高实验教学质量, 改革与实践 改革与实践(六),中山大学出版社 1999年,18 汪波,季凤英,许遵乐 采用多层次课堂讨论,加强有机化学理论教学 中国化学会第三届全国生物学科化学教学研讨会 1999年11月,上海,论文集p19 汪波,许遵乐 开展提前介入科研活动,培养创新人才 改革与实践(七),中山大学出版社 2000,20. Tan, D-M; Li, H-H;Wang, B; Liu H-B; Xu, Z-L. “A Novel Domino Reaction of 1,1"-Bi-2-naphthol Catalyzed by Copper(II)-amine Complexes”,Chinese Journal of Chemistry, 2001, 19(1), 91-9621. 谭端明,吴建安,汪波,许遵乐,“一个得到1,1‘-联-2-萘胺的合成新方法”,有机化学,2001, 21(1), 64-6522. Gao, M-Z;Wang, B; Liu, H-B; Xu, Z-L. “Synthesis of Chiral 2,5-Bis(oxazolinyl)thiophenes and Their applications as Chiral Shift Reagents for 1,1"-Bi-2-naphthols”,Chinese Journal of Chemistry, 2002, 20(1), 85-8923. 高明章,汪波,许遵乐,“C2型轴对称手性恶唑啉的合成及其应用研究进展”,化学进展,2002, 14(5), 347-354(综述)24. 谭端明,赵佩瑜,吴建安,汪波,姚骏骅,刘汉标,许遵乐,“铜(II)化合物作用下20萘胺的氧化偶合反应”,化学学报,2002, 60(10), 1854-185925. 庞冀燕,陈之朋,汪波,许遵乐,“多官能团有机羧酸在KF 2H2O催化下的酯化反应”,中山大学学报(自然科学版),2002, 41(6), 46-4826. 李伟杰,汪波,许遵乐,“N,N-二甲基氨基乙酸酯的合成及其应用研究”,中山大学学报(自然科学版),2003, 42(6), 44-4627. 李伟杰,汪波,姚骏骅,许遵乐,“手性恶唑啉的合成及其在不对称还原反应中的应用”,有机化学,2004, 24(10), 1239-124328. S.-D. Tan, W.-H. Chen, A. Satake,B. Wang, Z.-L. Xu and Y. Kobuke, “Tetracyanoresorcin[4]arene as a pH Dependent Artificial Acetylcholine Receptor”,Org. Biomol. Chem., 2004, 2, 2719-2721 (Chem. Biol. Virtual J., 2004, issue 18)29. Gao, Ming Zhang; Reibenspies, Joseph H;Wang, Bo; Xu, Zun Le; Zingaro, Ralph A.Journal of Heterocyclic Chemistry, 2004, 41(6), 899-90830. Gao, Ming Zhang;Wang, Bo; Kong, Deyuan; Zingaro, Ralph A; Clearfield, Abraham; Xu Zun Le. “Sulfur-containing chiral bis(oxazolines)tested in copper-catalyzed asymmetric cyclopropanation”,Synthetic Communications, 2005, 35(20), 2665-267331. 庞冀燕,汪波,陈之朋,许遵乐,“2-取代芳基苯并[b]呋喃类化合物的合成”有机化学,2005, 25(2), 176-18132. Hu, Sheng; Chen, Jing-Cai; Tong, Ming-Liang;Wang, Bo; Yan, Yun-Xin; Batten, Stuart R. “Cu2+-Mediated Dehydrogenative Coupling and Hydroxylation of an N-Heterocyclic Ligand: From Generation of a New Tetratopic Ligand to the Designed Assembly of Three-Dimensional Copper(i) Coordination Polymers”,Angew. Chem., Int. Ed., 2005, 44, 5471-547533. 陈之朋,庞冀燕,汪波,许遵乐。二苯并呫吨类化合物的环氧化反应研究。有机化学,2005, 10, 1274~127。34. Chen, Wen-Hua; Wei, Ying; Tan, Song-De;Wang, Bo; Xu, Zun-Le; “ Spectromitric Study of the size discrimination of quaternary ammonium cations by tetracyanoresorcin[4]arene”,Supramolecular Chemistry, 2005, 17(6), 469-47335. 王秀珍,庞冀燕,汪波,许遵乐。铜胺络合物作用下取代2-萘酚的交叉偶合反应。有机化学,2005, 7, 859-861。36. 郭礼荣,汪波,冯小龙,谭民裕,鲁统部,“两个7-氧杂-二苯芴-3,11-二磺酸镉化合物的合成、结构与荧光性质研究(英文)”,无机化学学报,2005, 21(7), 987-992。37. Ming-Hua Zeng,Bo Wang, Xin-Yi Wang, Wei-Xiong Zhang, Xiao-Ming Chen,*, and Song Gao*, “Chiral Magnetic Metal-Organic Frameworks of Dimetal Subunits:Magnetism Tuning by Mixed-Metal Compositions of the Solid Solutions”,Inorg. Chem. 2006, 45, 7069-7076.38. Shan, Hong-bo; Cai, Yu-chen; Liu, Yan; Zeng, Wen-nan; Chen, Hui-xiong; Fan, Bo-tao; Liu, Xu-hui; Xu, Zun-le;Wang, Bo*; Xian, Li-jian*. “Cytotoxicity of cantharidin analogues targeting protein phosphatase 2A”,Anti-Cancer Drugs, 2006, 17(8), 905-9115. Yan Liu, Lan Zou, Lin Ma, Wen-Hua Chen,Bo Wang* and Zun-Le Xu, “Synthesis and pharmacological activities of xanthone derivatives as a-glucosidase inhibitors”,Bioganic & Medicinal Chemistry, 2006, 14(16), 5683-5690.39. Xiong-Zhong Sun, Ming-Hua Zeng,Bo Wang, Bao-Hui Ye, Xiao-Ming Chen; Supramolecular architectures of metallomacrocyclic and coordination polymers with dicarboxylate and 4, 4"-bis(imidazol-1-ylmethyl)- biphenyl ligand,Journal of Molecular Structure2007, 828, 10-1440. Yan Liu, Lin Ma, Wen-Hua Chen,Bo Wang* and Zun-Le Xu; Synthesis of xanthone derivatives with extended p-systems as a-glucosidase inhibitors: Insight into the probable binding mode,Bioorganic & Medicinal Chemistry, 2007, 15(8), 2810-281441. Ai-Yun Peng,* Xun Yang,Bo Wang, “Synthesis and reactions of phosphaisocoumarins”,Phosphorus, Sulfur, Silicon, and Related Elements, 2008, 183, 665-666.42. Yan Liu, Zhuofeng Ke, Jianfang Cui, Wen-Hua Chen, Lin Ma, Bo Wang *; Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as a-glucosidase inhibitors, Bioorganic & Medicinal Chemistry, 2008, 16, 7185-71922023-07-30 04:50:291
孟卫东的简介
1、 获2006年上海市科技进步三等奖(第二单位);2、 获2004年香港“桑麻”基金会“桑麻”奖教金 1、含脂羊毛中昆虫生长抑制剂残留的检测,上海出入境检验检疫局委托,4万元,2005-2006,主持,已结题。2、含短氟碳链的含氟整理剂的合成及应用,教育部创新团队子项目,5万元,2006-2007,主持。3、含短氟碳链水性聚氨酯的合成及在纺织品上的应用,中科院有机氟化学重点实验室开放课题,1.5万元,2006-2007,主持。4、拒水、拒油、防污丝绸用含氟硅有机化合物的分子设计与合成,教育部重点研究项目(重点01082),9万元,2001―2003,已结题,第二。5、新型含三氟甲基合成子的制备与应用,国家自然科学基金面上项目,21万元,2003―2006,已结题,第二。6、氟碳相硼烷的制备与应用,上海市科委重点研究项目,20万元,2003―2005,已鉴定,第二。7、有机氟化学,国家自然科学基金委“杰出青年”基金(20325210),100万元,2004―2007,第二。8、手性有机氟化合物的合成及其应用,教育部重点研究项目(104194),18万元,2004-2007,第二。 1、Wei-Dong Meng, Zhi-Hang Zhang, Feng-Ling Qing, Qing Li, Yue-yue Zhang, Hui-Sheng Wang. Synthesis of gem-difluoromethylenated daidzein analogues and their inhibitory effect on U2OS cell cycle. Pharmazie, 2006, 61, 648-649.(SCI 收录).2、Wei-Dong Meng, Feng-Ling Qing. Fluorinated Nucleosides as Antiviral and Antitumor Agents. Current Topics in Medicinal Chemistry, 2006, 6, 1499-1528. (SCI收录).3、Wan-chao Jiang, Wei-dong Meng,Feng-ling Qing A novel perfluorooctylated triazine pyridine quaternary ammonium salt: synthesis and its application on cotton fabrics finishing Journal of Applied Polymer Sciences,2006, 100,4561.(SCI收录)4、Chun-Yan Wang, Wei-Dong Meng, Yan-Gen Huang, Feng-Ling QingThe synthesis and application of fluorous boronates without perfluorinated solvents. J. Fluorine Chem. 2005, 126, 996.(SCI收录)5、Wan-Chao Jiang, Wei-Dong Meng and Feng-Ling Qing. Synthesis of A Novel Perfluorooctylated Polyacrylate and Its Application on Cotton Fabrics. Journal of Applied Polymer Sciences 2005, 98, 222.(SCI收录)6、Wan-Chao Jiang, Wei-Dong Meng and Feng-Ling Qing, A Novel Perfluoroalkyl-conataining Bissulfite Adduct of Polyisocyanate. Textile Res. J. 2005, 75, 240.(SCI收录)7、Wan-Chao Jiang, Wei-Dong Meng and Feng-Ling Qing, Application of Bisulfite Adduct of Polyisocyanate on Cotton Fabrics as a Durable Press Finishing Agent. Textile Res. J. 2005, 75, 39.(SCI收录)8、Xing Zheng,Wei-Dong Mengand Feng-Ling Qing.Synthesis of gem-difluoromethylenated biflavonoid via the Suzuki coupling reaction. Tetrahedron Lett. 2004, 45, 8083.(SCI收录)9、Hui Shao, Wei-Dong Meng and Feng-Ling Qing, Synthesis and application of a novel perfluoroalkyl-containing quaternary ammonium salt. J. Fluorine Chem. 2004, 125, 721.(SCI收录)10、Xing Zheng, Wei-Dong Meng , Yang-Yan Xu, Jian-Guo Cao and Feng-Ling QingSynthesis and anticancer effect of chrysin derivatives Bioorg. Med. Chem. Lett., 2003, 13, 881.(SCI收录)11、Cai-Ling Wang, Xing Zheng, Wei-Dong Meng,Hong-Qi Liand Feng-Ling QingUnexpected formation of 3-alkylated flavonoids in the alkylation of B-ring substituted 5.7-dihydroxy flavones Tetrahedron Lett. 2005, 46, 5399.(SCI收录)12、Cai-Ling Wang, Hong-Qi Li, Wei CDong Mengand Feng-Ling Qing Trifluoromethylation of Flavonoids and Anti-tumor Activity of the Trifluoromethylated Flavonoid DerivativesBioorg. Med. Chem. Lett., 2005, 15, 4456.(SCI收录)13、Yan-Yan Yang,Wei-Dong Meng and Feng-Ling Qing. Synthesis of 2",3"-Dideoxy-6",6" -difluorocarbocyclic Nucleosides. Organic Lett. 2004, 6, 4257。(SCI收录)14、Xiao-Long Qiu, Wei-Dong Meng and Feng-Ling Qing.Synthesis of fluorinated amino acids. Tetrahedron, 2004, 6711.(SCI收录)15、Hui Shao, Jian-Ying Sun, Wei-Dong Meng and Feng-Ling Qing, Water and oil repellent and durable press finishes for cotton based on a perfluoroalkyl-containing muitiepoxy compound and citric acid.Textile Res. J. 2004, 74, 851.(SCI收录)16、Yangen Huang, Wei-Dong Meng and Feng-Ling Qing, Fluorous osmium tetroxide (FOsO4): a recoverable and reusable catalyst for dihydroxylation of olefins. Tetrahedron Lett., 2004, 45, 1965.(SCI收录)17、Hui Shao, Li Jiang, Wei-Dong Meng, Feng-Ling Qing, Synthesis and antimicrobial activity of a perfluoroalkyl-containing ammonium salt. J. Fluorine Chem., 2003, 124, 89.(SCI收录)18、Xing Zheng, Jian-Guo Cao, Wei-Dong Meng and Feng-Ling QingSynthesis and anticancer effect of B-ring trifluoromethylated flavonoidsBioorg. Med. Chem. Lett., 2003, 13, 3423. 有机化学(双语教学), 有机合成化学(硕士课程)请点击东华大学,化生学院,师资力量,教授中寻找联系方式 。(编辑:殷江辉,王刚,张煊 学生李旭东)2023-07-30 04:50:431
科学英语名言
1、科学的每一项巨大成就,都是以大胆的幻想为出发点的。 Every great achievement of science is based on bold fantasies. 2、所有的科学都是错误先真理而生,错误在先比错误在后好。 All science is born of error and truth, before mistakes are better than mistakes. 3、对搞科学的人来说,勤奋就是成功之母。 To the science of science, diligence is the mother of success. 4、科学是老老实实的东西,它要靠许许多多人民的劳动和智慧积累起来。 Science is an old and honest thing, and it must be accumulated by the labor and wisdom of many people. 5、科学的基础是健康的身体。 The foundation of science is a healthy body. 6、科学还不只在智慧训练上是最好的,在首选训练上也是一样。 Science is not only the best in the training of wisdom, but also the same in the first choice of training. 7、一分时间,一分成果。对科学工作者来说,就不是一天八小时,而是寸阴必珍,寸阳必争。 One minute, one point. For the scientific workers, not eight hours a day, but the time carefully for Jane, "yang. 8、学科学,是一口气也松不得的;科学的成就就是毅力加耐性。 Science is not at one breath; the achievement of science is perseverance and perseverance. 9、不要因为长期埋头科学,而失去对生活、对美、对待诗意的感受能力。 Don"t lose the ability to feel about life, to beauty and to poetry because of long-term science. 10、好奇心造就科学家和诗人。 Curiosity makes scientists and poets. 11、我首先要求诸君信任科学,相信理性,信任自己,并相信自己。 I first asked you trust science, believe in reason, trust in yourself, and believe in yourself. 12、真正的科学不知道同情,也不知道厌恶,它的惟一目的就是真理。 True science does not know sympathy, nor does it know disgust. It is the only purpose of truth. 13、科学没有国境,但科学家有祖国。 Science has no borders, but scientists have the motherland. 14、优秀的科学家必定是某种程度的狂人。 A good scientist must be a man of some degree. 15、科学家不创造任何东西,而是揭示自然界中现成的隐藏着的真实,艺术家创造真实的类似物。 Scientists do not create anything, but reveal the hidden truth in nature, and artists create real analogues. 16、科学是没有国界的,因为她是属于全人类的财富,是照亮世界的火把,但学者是属于祖国的。 Science is not national boundaries, because she belongs to the wealth of all mankind, is the torch to illuminate the world, but the scholars belong to the motherland. 17、科学的种子,是为了人民的收获而生长的。 The seed of science is grown for the harvest of the people. 18、热爱科学就是热爱真理,因此,诚实是科学家的主要美德。 Love of science is the love of truth, and therefore honesty is the main virtue of a scientist. 19、科学的宗旨就是提供宇宙的真正写真。 The purpose of science is to provide real portraits of the universe. 20、科学是一种强大的智慧的力量,它致力于破除禁锢着我的神秘的桎梏。 Science is a powerful force of wisdom, and it is committed to removing the mysterious shackles that imprison me. 21、真正的科学家应当是个幻想家;谁不是幻想家,谁就只能把自己称为实践家。 Real scientists should be a visionary; who is not a visionary, who can only refer to themselves as practitioners. 22、科学既是人类智慧的最高成果,又是最有希望的物质福利的源泉。 Science is not only the highest achievement of human wisdom, but also the most promising source of material welfare. 23、科学的惟一目的是减轻人类生存的苦难,科学家应为大多数人着想。 The only purpose of science is to reduce the suffering of human existence, and scientists should think for the majority of people. 24、科学的伟大进步,来源于崭新与大胆的想像力。 The great progress of science comes from new and bold imagination. 25、科学尊重事实,不能胡乱编造理由来附会一部学说。 Science can not respect the facts, make up a reason given theory. 26、科学家的成果是全人类的财产,而科学是最无私的领域。 The results of scientists are the property of all human beings, and science is the most selfless field. 27、科学就是不断地认识,不仅是发现,而且是发明。 Science is the constant understanding, not only the discovery, but also the invention. 28、科学成就是由一点一滴积累起来的,惟有长期的积聚才能由点滴汇成大海。 Scientific achievements are accumulated by little and one bit, but only a long time can be accumulated in order to sink into the sea. 29、社会一旦有技术上的需要,则这种需要就会比十所大学更能把科学推向前进。 Once a society has a technical need, it will push science forward more than ten universities. 30、在科学工作中,不愿意越过事实前进一步的人,很少能理解事实。 In scientific work, people who do not want to move across the facts are rarely able to understand the facts. 31、你要知道科学方法的实质,不要去听一个科学家对你说些什么,而要仔细看他在做什么。 You need to know the essence of the method of science. Do not listen to what a scientist says to you, but look carefully at what he is doing. 32、科学是到处为家的,不过,在任何不播种的地方,是决不会得到丰收的。 Science is home everywhere, but in any place that does not sow, it will never get a good harvest. 33、科学技术是第一生产力。 Science and technology are the first productive forces. 34、我之所以能在科学上成功,最重要的一点就是对科学的热爱,坚持长期探索。 The most important thing that I can be able to succeed in science is the love of science and the persistence of long-term exploration. 35、追求科学需要特殊的勇敢。 The pursuit of science requires special courage. 36、德行啊!你是纯朴的灵魂的崇高科学。 Virtue! You are the noble science of the pure soul. 37、科学不能或者不愿影响到自己民族以外,是不配称作科学的。 Science can not, or do not want to affect, other than its own nation, which is not worthy of being called science. 38、科学地探求真理,要求我们的理智永远不要狂热地坚持某种假设。 The scientific search for truth requires our intellect never to stick to a certain hypothesis fanatically. 39、德行使心灵明晰,使人不仅更易了解德行,而且也更易了解科学的真理。 Virtue makes the mind clear, making people not only more aware of virtue, but also more easy to understand the truth of science. 40、如果学习只在于模仿,那么我们就不会有科学,也不会有技术。 If learning is only imitation, we will not have science, and there will be no technology. 41、道德应当成为科学的指路明灯。 Morality should be the guiding light of science. 42、我要把人生变成科学的梦,然后再把梦变成现实。 I want to turn life into a dream of science, and then turn the dream into reality. 43、在科学上没有平坦的大道,只有不畏劳苦沿着陡峭山路攀登的人,才有希望达到光辉的顶点。 There is no smooth road in science, and only those who do not fear the hard work to climb along the steep mountains have the chance to reach a brilliant point. 44、一旦科学插上幻想的翅膀,它就能赢得胜利。 Once science has the wings of fantasy, it will win. 45、没有疑问,哲学与科学在许多方面是互相促进的。 There is no doubt that philosophy and science promote each other in many ways. 46、攻克科学堡垒,就像打仗一样,总会有人牺牲,有人受伤,我要为科学而献身。 The fortress of science, like a war, will always be sacrificed, someone is injured, and I want to devote myself to science. 47、幻想是诗人的翅膀,假设是科学的天梯。 Fantasy is the poet"s wings, the scientific hypothesis is the ladder. 48、再没有别的任何艺术或科学,比**艺术或**科学更困难的了。 No other art or science is more difficult than the art of war or the science of war. 49、青年的敏感和独创精神,一经与成熟科学家丰富的知识和经验相结合,就能相得益彰。 The sensitivities and originality of the young are combined with the rich knowledge and experience of the mature scientists to complement each other. 50、智慧不属于恶毒的心灵,没有良心的科学只是灵魂的毁灭。 Wisdom does not belong to the evil spirit, and the science without conscience is only the destruction of the soul. 51、在学习中,在劳动中,在科学中,在为人民的忘我服务中,你可以找到自己的幸福。 In the study, in the work, in science, in the unselfish service of the people, you can find your own happiness. 52、科学是人类积累的知识的巨大宝库。 Science is a huge treasure house of knowledge accumulated by human beings. 53、科学的界限就像地平线一样:你越接近它,它挪得越远。 The boundaries of science are like the horizon: the closer you get to it, the farther it moves. 54、科学是人类的共同财富,而真正的科学家的任务就是丰富这个令人类都能受益的知识宝库。 Science is the common wealth of mankind, and the task of real scientists is to enrich the treasure house of knowledge that can benefit mankind. 55、在科学上最好的助手是自己的头脑,而不是别的东西。 The best assistant in science is his own mind, not something else. 56、感谢科学,它不仅使生活充满快乐与欢欣,并且给生活以支柱和自尊心。 Thanks to science, it not only makes life full of happiness and joy, but also gives life a pillar and pride. 57、科学不是为了个人荣誉,不是为了私利,而是为人类谋幸福。 Science is not for personal honor, not for selfish interests, but for human happiness. 58、在任何科学上的雏形,都有它双重的形象:胚胎时的丑恶,萌芽时的美丽。 In the embryonic form of any science, it has its dual image: the ugly in the embryo and the beauty in the bud. 59、真理只有一个,它不在宗教中,而是在科学中。 There is only one truth, it is not in religion, but in science. 60、人的一生就是这样,先把人生变成一个科学的梦,然后再把梦变成现实。 This is the life of a person, first turning life into a scientific dream, and then turning the dream into reality. 61、科学家一旦做出成绩,就应该忘记自己所做的事情,而经常去考虑他应该做的事情。 Once a scientist makes a result, he should forget what he does, and often think about what he should do. 62、科学的真正的与合理的目的在于造福于人类生活,用新的发明和财富丰富人类生活。 The true and reasonable purpose of science is to benefit human life, and to enrich human life with new inventions and wealth. 63、科学如同大海,要求奋不顾身的拼搏。 Science is like the sea, demanding hard work. 64、在科学思维中常常伴着诗的因素,真正的科学和真正的音乐要求同样的想象过程。 In scientific thinking often accompanied by the factors of poetry, real science and real music require the same imaginary process. 65、任何人都承认实验是科学之母,这是确定不移的真理,谁也不会否认。 Anyone will admit that the experiment is the mother of science, which is a true truth, and no one will deny it. 66、科学需要人的全部生命。 Science needs all the life of the man. 67、要学会做科学中的粗活。要研究事实,对比事实,积聚事实。 To learn how to do science. To study facts, to compare facts, to accumulate facts. 68、从科学园地采收的果实,如同农人的收获一样,常常是工作与幸运和有利的情势的共同产物。 The fruit harvested from a scientific garden, like the harvest of a farmer, is often a common product of work and luck and favorable circumstances. 69、科学的事业就是为人民服务。 The cause of science is to serve the people. 70、万事开头难,每门科学都是如此。 Everything is difficult at the beginning, and every science is so. 71、惊奇就是科学的种子。 Surprise is the seed of science. 72、正像新生的婴儿一样,科学的真理必将在斗争中不断发展,广泛传播,无往而不胜。 Just like newborn babies, the truth of science will continue to develop in the struggle, sPad widely, and never win. 73、没有思想自由,就没有科学,没有真理。 Without freedom of thought, there is no science, no truth. 74、搞科学工作需要人的全部生命,八小时工作制是行不通的。 Scientific work requires all human life, and eight hours of work is not feasible. 75、在科学上进步而道义上落后的人,不是前进,而是后退。 The man who is backward in scientific progress and moral is not forward, but backward. 76、科学也需要创造,需要幻想,有幻想才能打破传统的束缚,才能发展科学。 Science also needs to be created. It needs fantasy and fantasy to break the bondage of tradition to develop science. 77、科学研究能破除迷信,因为它鼓励人们根据因果关系来思考和观察事物。 Scientific research to superstition, because it encourages people to think and observe things according to the causal relationship. 78、天才是不足恃的,聪明是不可靠的,要想顺手拣来的伟大科学发明是不可想象的。 Genius is unreliable, smart is not reliable, easy to pick up the great scientific invention is unthinkable. 79、科学总是**的、非正统的;这是它的本性;只有科学在睡大觉时才不如此。 Science is always revolutionary and unorthodox; it is its nature; it is the only thing that is not the case when science is asleep. 80、教师必须具有健康的体魄,农人的身手,科学的头脑,艺术的兴味,改革社会的精神。 Teachers must have a healthy body, the hands of the peasants, the scientific mind, the taste of the art, and the spirit of the society.2023-07-30 04:51:041
田红旗的人物生涯
教育经历:1990年7月本科毕业于四川大学化学系,1998年获中科院上海有机化学研究所博士。工作经历2010年6月至今,南开大学药学院教授,博士生导师;2001年6月至今,阿瑞制药公司, 高级研究科学家(Senior Research Scientist);1998年9月至2001年5月,科罗拉多大学化学系博士后;1990年7月至1993年8月,原化学工业部感光化学研究院助理工程师。本人特长通过结构-活性关系(SAR)的研究对先导化合物进行最佳优化来开发新药;对受体蛋白激酶领域的靶标受体有一定程度的了解,并据此提出治疗癌症的新药开发的项目;具有开发新有机反应方法学研究的特长;具有对有机化合物进行工业化工艺研究的特长;熟悉通过各种分析仪器(如核磁共振、液-质联用仪、液相色谱、气相色谱、红外和质谱仪等)对有机化合物进行结构确定,及其他各种所需要的特征化。发表的文章1. Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety. T. Richardson; S. Frank; M. Wang; C. Clarke; S. Jones; B. Ying; D. Kohlman; O. Wallace; T. Shepherd; R. Dally; A. Palkowitz; A. Geiser; H. Bryant; J. Henck; I. Cohen; D. Rudmann; D. McCann; D. Coutant; S. Oldham; C. Hummel; K. Fong; R. Hinklin; G. Lewis; H. Tian; J. Dodge. Bioorganic & Medicinal Chemistry Letters, 2007, 17(13), 3544-3549.2. A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats. C. Hummel; A. Geiser; H. Bryant; I. Cohen; R. Dally; K. Fong; S. Frank; R. Hinklin; S. Jones; G. Lewis; D. McCann; D. Rudmann; T. Shepherd; H. Tian; O. Wallace; M. Wang; Y. Wang; J. Dodge. Journal of Medicinal Chemistry, 2005, 48(22), 6772-6775.3. Asymmetric Strecker Reaction of g-Keto Acids. Facile Entry to a-Substituted and a,g-Disubstituted Glutamic Acids. G. Tang, H. Tian, D. Ma*, Tetrahedron, 2004, 60(46), 10547-10552.4. Asymmetric Synthesis of (S)-1-Aminoindan-1,5-dicarboxylic Acid and Related Analogues via Intramolecular Acylation of Enantiopure α,α-Disubtituted Amino Acids. D. Ma*, D. Ke, H. Tian, B. Wang, D. Cheng, Tetrahedron: Asymmetry, 2002, 13(9), 961-969.5. Designing New Chiral Ketone Catalysts. Enantioselective Epoxidation of cis- and Terminal Olefins, H. Tian, X. She, H. Yu, L. Shu, Y. Shi*, J. Org. Chem., 2002, 67(8), 2435-2446.6. Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxriane, H. Tian, X. She, J. Xu, Y. Shi*, Org. Lett., 2001, 3(12), 1929-1931.7. Electronic Probing of Ketone Catalysts for Asymmetric Epoxidation. Search for More Robust Catalyst, H. Tian, X. She, Y. Shi*, Org. Lett., 2001, 3(5), 715-718.8. Highly Enantioselective Epoxidation of cis-Olefins by Chiral Dioxirane, H. Tian, X. She, L. Shu, H. Yu, Y. Shi*, J. Am. Chem. Soc., 2000, 122, 11551-11552.9. Oxidation of Benzylic Methylene Compounds to Ketones with m- Chloroperoxybenzoic Acid and Oxygen, D. Ma*, C. Xia, H. Tian, Tetrahedron Lett. 1999, 40(50), 8915-8917.10. Enantioselective Syntheses of a-Substituted Glutamic Acids and a, g- Disubstituted Glutamic Acids by an Asymmetric Strecker Reaction, D. Ma*, G. Tang, H. Tian, G. Zou, Tetrahedron Lett. 1999, 40(31), 5753-5756.11. Asymmetric Strecker-Type Reaction of a-Aryl Ketones. Synthesis of s-aM4CPG, s-MPPG, s-AIDA, and s-APICA, the Antagonists of Metabotropic Glutamate Receptors, D. Ma*, H. Tian, G. Zou, J. Org. Chem., 1999, 64(1), 120-125.12. Stereoselective Synthesis of s-MPPG, s-MTPG, and s-(+)-aM4CPG from R-4-Hydroxyphenylglycine, D. Ma*, H. Tian, J. Chem. Soc. Perkin. Transactions I, 1997, 23, 3493-3496.13. Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Receptor Antagonists, D. Ma*, H. Tian, H. Sun, A. P. Kozikowski, S. Pshenichkin, J. T. Wroblewsk, Biorg. & Med. Chem. Lett., 1997, 7(9), 1195-1198.14. Asymmetric Synthesis of (+)-4CPMG, a Selective Antagonist of Metabotropic Glutamate Receptors, D. Ma*, H. Tian. Tetrahedron: Asymmetry, 1996, 7(6), 1567-1570.发表的专利1. Preparation of pyrrolidinone and piperidinone derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace.2. Preparation of pyrrolidones and piperidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace; A. Krasutsky; J. Allen.3. Preparation of cycloalkyl lactam derivatives, particularly N-substituted pyrrolidin-2-ones, as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace; Z. Chen; T. Mabry; J. Mccowan; N. Snyder; L. Winneroski; J. Allen.4. Heterobicyclic thiophene compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; J. DeMeese; J. Gaudino; A. Marlow; J. Seo; A. Thomas; H. Tian. US 2007197537.5. Heterobicyclic pyrazole compounds as Met tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; F. Cohen; J DeMeese; K. Fong; J. Gaudino; T. Kaplan; A. Marlow; J. Seo; A. Thomas; H. Tian; W. Young.6. Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; P. Anzeveno; A. Krasutsky; R. Li; T. Mabry; A. Saeed; N. Snyder; G. Stephenson; H. Tian; O. Wallace; L. Winneroski; Y. Xu. (Note: this patent had been applied to additional 16 countries besides of the counties designated in WO).7. Preparation of quinoline derivatives as tyrosine kinases inhibitors. J. Gaudino; S. Boyd; A. Marlow; T. Kaplan; K. Fong; J. Seo; H. Tian; J. Blake; K. Koch.8. Heterobicyclic Pyrazolopyridine Compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; F. Cohen; J DeMeese; K. Fong; J. Gaudino; A. Marlow; J. Seo; A. Thomas; H. Tian; W. Young. Had been applied.9. Heterobicyclic Azaindole Compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; K. Fong; J. Gaudino; H. Tian. Manuscript in preparation.2023-07-30 04:51:121
环二肽的相关资料
环二肽是目前发现最小的环肽,结构稳定,如果你说的是农业上的话,建议你查查智能聪环二肽,是山东蓬勃生物科技有限公司首次将环二肽商业化使用到农业上2023-07-30 04:51:302
帮忙翻译
yes,i agree on the second floor"s opinion2023-07-30 04:51:513
adenylate adenosine 什么区别
区别是:adenylate指的是:腺苷酸、腺苷酸盐。adenosine指的是:腺苷。例句:adenylate1、PACAP, Rat pituitary adenylate cyclase activating polypeptide. 大鼠垂体腺苷酸环化酶激活肽。2、Unnatural amino acid site-directed mutagenesis was applied to adenylate kinase tostudy its mechanism. 非天然氨基酸定点突变成功地应用在腺苷酸激酶上来研究其作用机理。3、Effects of Sevoflurane on Adenylate Cyclase and Phosphodiesterases Activity inBrain of Rats 七氟烷对大鼠脑内腺苷酸环化酶及磷酸二酯酶活性的影响adenosine1、They found a24-fold rise in adenosine, which seemed promising. 他们发现采样中的腺苷增加了24倍,看来该研究有希望了。2、The effect of adenosine and its analogues on the phosphorylation of phosphatidy linositol in pig erythrocyte ghosts was investigated. 本文研究了腺苷及其类似物对猪红细胞膜上磷脂酰肌醇磷酸化的影响。3、Through a series of experiments, the UNC researchers showed that PAP removesthe phosphate group, generating adenosine. UNC的研究者通过一系列的实验证明,PAP移除了磷酸基团,产生了腺苷酸。2023-07-30 04:51:581
论文摘要求翻译
从菊科植物大花金挖耳是一种韩国少见的植物,已经被用于韩国民间医学,做为一种退热,镇痛,驱虫,疼痛缓解和消炎的药物.......2023-07-30 04:52:062
化学论文翻译!
通信 在( - )- Penifulvin甲,一个具有Dioxafenestrane骨架全合成杀虫剂 摘要 我们在此报告的Penifulvin甲,一个新的二氧杂窗烷结构的倍半萜的首次全合成。 Penifulvin A是针对秋季夜蛾夜蛾造成了消费领域的各种作物的枝叶在美国的巨大破坏烈性杀虫剂。五步消旋和8步不对称路由到天然产品,其绝对构型确定描述。关键步骤是元光环,让快速访问一个立体的方式对penifulvin碳骨架。最后一氧化级联导致的必然产物。该合成路线是从保护团体的自由,可扩展,灵活,不同的类似物,其中penifulvins乙娥,应履行的杀虫作用特区测试可用。 通信 统一亚铁合成磁铁矿Nanocubes 摘要 我们合成的尺寸范围从20到160纳米的统一亚铁磁铁矿nanocubes。该nanocubes磁性的特点,以及磁选组氨酸标签的蛋白质证明。 通信 阿单抗体催化多种化学物质变换的功能化后,小非蛋白成分替换 摘要 单一催化抗体后,小nonportein的funcctionalized更换元件多种化学物质转变。 通信 超临界加工作为干线至偏高内部表面积和常驻微孔在金属有机骨架材料 摘要 四个代表金属有机骨架(MOF)的液体和超临界二氧化碳(SCD)的材料,仔细处理导致重大,或在某些情况下壮观(高达1200%),气体的增加,表面积。表面积最大化的关键在于优化的MOFs许多潜在的应用。初步证据表明,孔崩溃的抑制,因此微孔无障碍作为ScD内非常有效的成果为基础的基础,激活。2023-07-30 04:52:154
OPC-3的研究文献(Scientific Studies)
1. Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.2. Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.3. Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.4. Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.5. Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.6. Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.7. Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.8. Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.9. Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.10. Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.11. Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.12. Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh13. Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.14. Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.15. Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.16. Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.17. Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.18. Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.19. Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.20. Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.21. Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.22. Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.23. Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.24. Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.25. Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.26. Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.27. Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.28. Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.29. Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.30. Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.31. Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.32. Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.33. Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.34. Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.35. Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.36. Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.37. Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.38. Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.39. Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.40. Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.41. Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.42. Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.43. Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.44. Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.45. Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.46. Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.47. Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.48. Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.49. Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.50. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.51. Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.52. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.53. Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.54. Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.55. Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.56. Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.57. Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.58. Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.59. Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.60. Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.61. Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.62. Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.63. Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.64. Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.65. Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.2023-07-30 04:52:321
翻译 不要翻译器翻译的
目前,bioimprinting几种脂肪酶在不同的支持材料一直报道[9,10]。然而,没有出现过报告对洋葱伯克霍尔德菌脂肪酶的bioimprinting溶胶凝胶法。洋葱伯克霍尔德菌脂肪酶是一种生物催化剂中经常使用非水介质[12,13]。在本文中,为了提高其性能和拓宽其应用领域,B的bioimprinting菌脂肪酶的酶进行预处理与在衬底溶胶凝胶法脂肪酸类似物,并themain因素有关这一processwere系统的研究以取得最佳的条件。热稳定性和酒精固定化研究lipaseswere宽容,并有可能对酶的活性增强的印迹也在表面结构加以讨论,比表面积和硅烷粒子的平均孔径。2023-07-30 04:52:582
有谁可以帮我翻译一下。
太专业了,文科的我,完全不能了解,虽然很想帮你。。2023-07-30 04:53:062
帮忙翻译一下
提高洋葱伯克霍尔德菌脂酶活性封装在酯化 二氧化硅与底物类似物bioimprinting http://www.hao123.com/ss/fy.htm 在线翻译2023-07-30 04:53:222
刘忠的主要论文:
1. Wang SX, Ju HQ, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z*, Wang YF*. SNX -2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells. Biosci Biotech Bioch. 2011, 75(8): 1540-1545.2. Liu JY*, Liu Z*, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF, Yang DP. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011, 190(2-3): 91-101. (*, co-first author)3. Liu Z, Huang SL, Li MM, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by mansonone F analogues: implications for anticancer activity. Chem Biol Interact. 2009, 177(1): 48-57.4. Liu Z, Du ZY, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by curcumin analogs. Biosci Biotech Bioch. 2008, 72(8): 2214-2218.5. Qiu X*, Liu Z*, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ, Huang ZS, Gu LQ. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors. Bioorg Med Chem. 2008, 16(17): 8035-8041. (*, co-first author)6. Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C. Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete. Org Lett, 2012, 14 (13), 3364–3367.7. He F, Liu Z, Yang J, Fu P, Peng J, Zhu WM, Qi SH. A novel antifouling alkaloid from halotolerant fungus Penicillium sp. OUCMDZ-776, Tetrahedron Lett. 2012, 53(18): 2280-2283.8. Li MM, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL, Ye WC. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012, 83(9): 1251-1260.9. Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncol Rep. 2012, 27(6):1904-1910.10. Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX, Wang YF. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett. 2012, 318(2): 66-74.11. Zhang XQ, Xu FF, Wang L, Huang MY, Liu Z, Zhang DM, Wang GC, Li YL, Ye WC, Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem Lett. 2012, 5(2): 292-296.12. Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A, Zhang L. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 2012, DOI: 10.1021/np300221a13. Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, Wang YF. Preclinical pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomed Pharmacother. 2011, 65(2): 132-136.14. Sun F, Liu JY, He F, Liu Z, Wang R, Wang DM, Wang YF, Yang DP. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011, 13(8): 688-699.15. Ju HQ, Wang SX, Xiang YF, Liu Z, Liu JY, Chen ZP, Zeng FL, Xia M, Liu ZH, Xing GW, Wang SY, Wang YF. BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur J Pharmacol. 2011, 666: 26-34.16. Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Org Lett. 2010, 12(21):5040-5043.17. Zhou GX, Mo SY, He HX, Shi JG, Ye WC, Liu Z. Jiang RW, Molecular structure and tautomerization of the 1:1 complex of luteoskyrin and rugulosin J Mol Struct. 2010, 979(1): 86-91.18. Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC. Bufogargarizins A and B two novel 19-norbufadienolides with unprecedented skeletons from the venom of bufo bufo gargarizans. Chem Eur J. 2010, 16(36): 10989-10993.19. Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, Wang YF. Determination of SNX-2112, a selective Hsp90 inhibitor in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. J Pharm Biomed Anal. 2010, 53(4): 1048-1052.2023-07-30 04:53:301
急!汉译英,如果是翻译器翻译的就不用费事粘贴了
Natural medicinal chemistry is using the modern scientific theories and methods of chemical composition of natural medicine discipline, the main research natural drug chemical composition (the physiological activity component or the structure characteristics of drug ingredient) and physical and chemical properties, methods of extraction and separation, the structure identification method, etc. This paper summarizes the natural medicine, chemistry in China in recent years on the progress of natural medicines and, from a traditional folk medicine quantities of chemicals have been isolated, found that many of these compounds have good physiological activity, which not only with modern scientific method to research and develop the Chinese herbal medicine used, inherited the motherland medicine heritage, also has important significance to explore the mysteries of nature, the development and utilization of our rich natural resources, development in pharmaceutical business with characteristic of, have played an important role. In addition, but also to have certain physiological activity compounds for leading compounds the precursor, or that the molecular structure transform, increase its cure diseases including sex, remove the physiological adverse side effects, reduce toxicity, developed into new drugs and analogues and derivatives in the preparation of research, to add new content of medicinal chemistry. (*^__^*) 嘻嘻……2023-07-30 04:53:446
王志新的主要论著
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Zue010Xue010,Some Applications of Statistical Mechanics in Enzymology 4 Effects of pH on Enzyme,J.Theor.Biol.,1990,143:473~484. 16ue010Wang Xue010Cue010,Zhou Hue010Mue010,Wang Zue010Xue010,et alue010,Is the Subunit the Minimal Function Unit of Creatine Kinase,Biochim.Biophys.Acta.,1990,1039:313~317. 17ue010Wang Zue010Xue010,Kinetics of Suicide Substrates,J.Theor.Biol.,1990,147:497~ 508.18ue010王志新、赵康源,利用不可逆抑制剂区分予存不对称模型和诱导不对称模型的方法,生物 化学与生物物理学报,1991,23(1):47~53。 19ue010王志新、赵康源,滞后酶活性不可逆抑制的动力学,生物化学与生物物理学报,1991, 23(3):201~206。 20ue010Wang Zue010Xue010,Theoretical Considerations of the Tsou plot, J.Theor.Biol.,1991,150:437~450.21ue010Wang Zue010Xue010,Zhao Kue010Yue010,Kinetics of the Irreversible Modification of Enzyme Activity in Coupled Enzyme System I Only Primary Enzyme Modified by Reagent Y,Science in China,1992,35B:404~417.22ue010Wang Zue010Xue010,Zhao Kue010Yue010,Kinetics of the Irreversible Modification of Enzyme Activity in Coupled Enzyme System ⅡBoth Primary and Auxiliary Enzymes Modified by Reagent Y,Science in China,1992,35B:570~576.23ue010Sum Zue010Rue010,Zhao Kue010Yue010,Wang Zue010Xue010,et alue010,Quantitative Relation between Modification of Functional Groups of Protein and Their Biological Activity, Science in China,1992,35B:1341~1352.24ue010Wang Zue010Xue010,Wu Hue010Bue010,Wang Xue010Cue010,et alue010,Kinetics of the Course of Inactivation of Aminoacylase by 1,10ue011phenanthroline,Biochem J.,1992,281:285 ~290.25ue010Wang Zue010Xue010,Kumar Nue010Rue010,Srivastava Due010Kue010,A Novel Spectroscopictitration Method for Determining the Dissociation Constant and Stoichiometry of Proteinligand Complex,Anal.Biochem.,1992,206:376~381. 26ue010Johnson Jue010Kue010,Wang Zue010Xue010,Srivastava Due010Kue010,Mechanistic Investigation of Mediumue011chain Fatty Acylue011CoA Dehydrogenase Utilizing 3Indoleue011propionyl/acrylolylue011CoA as Chromophoric Substrate Analogues, Biochemistry,1992,31:10564~10575.27ue010Wang Zue010Xue010,Killilea Sue010Due010,Srivastava 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JSF技术现在怎么没有多少人用啊?不好用吗?
以后会慢慢好起来的,因为国内对jsf的重视程度不够,也很少有人能够用的好。所以目前用的人没有struts多。楼上的兄台,你能把struts和jsf一起用在一个项目中???那我真是太佩服你了2023-07-30 04:47:091
超清iTV是什么?
高清智能超清ITV是通过互联网接入、采用Android操作系统机顶盒或电视一体机,面向中国电信宽带用户提供的视频内容服务及互联网增值应用的业务。除了保留传统的基础直播、回看、点播功能,同时在智能家庭服务、游戏娱乐、智慧交互、高清影音等更多强扩展性功能,搭建家庭影音娱乐中心。2023-07-30 04:47:092
哪些英文单词可以表示“美丽”
cute lovelypretty2023-07-30 04:47:063
java中jsf框架为什么用的很少?
难搞,就用的少了。2023-07-30 04:47:023